Joshy Joseph

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During recent years, we have witnessed a major paradigm shift in distributed computing principles, with a focus towards service orientation, open standards integration, collaboration, and virtualization. One particular area of interest centers on the evolution of grid computing principles into the mainstream of distributed computing and Web services. In(More)
All organisms store the information necessary to maintain life in their DNA. Any process that damages DNA, causing a loss or corruption of that information, jeopardizes the viability of the organism. One-electron oxidation is such a process. In this Account, we address three of the central features of one-electron oxidation of DNA: (i) the migration of the(More)
The discovery that electron holes (radical cations) migrate long distances in DNA has fostered enormous interest in the mechanism of this processes, due in large part to its apparent similarity with oxidative damage in cells. 1,2 Several models have been proposed to account for the extensive experimental observations in this area. Currently, it is generally(More)
One-electron oxidation of A/T-rich DNA leads to mutations at thymine. Experimental investigation of DNA containing methyl-deuterated thymine reveals a large isotope effect establishing that cleavage of this carbon-hydrogen bond is involved in the rate-determining step of the reaction. First-principles quantum calculations reveal that the radical cation(More)
Grid computing enables resource sharing and dynamic allocation of distributed heterogeneous computational resources while minimizing the associated ownership and operating cost. In grid computing there is no matter where data located is or which computer processes a task. Quality of Service parameters plays a key role in selecting Grid resources and(More)
DNA-assisted Förster resonance energy transfer (FRET) between an anthracene-based cyclophane (CP) and mono- and bis-intercalators such as propidium iodide (PI) and ethidium homodimer-1 (EHD), respectively, has been studied using various photophysical and biophysical techniques. The cyclophane and PI exhibited simultaneous binding to DNA at all(More)
Oxidatively generated damage to DNA has been implicated as causing mutations that lead to aging and disease. The one-electron oxidation of normal DNA leads to formation of a nucleobase radical cation that hops through the DNA until it is trapped irreversibly, primarily by reaction at guanine. It has been observed that 5-methylcytosine (C(m)) is a mutational(More)
Efficient utilization of resources is the key factor for any environment. The grid environment is also more dynamic, it facilitates the movement of resources in and out of the environment flexibly. Hence maintenance of centralized registries is not sufficient for this demanding environment. Here, we propose a new approach for resource discovery which(More)
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