Joshua T. Schiffer
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AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
Despite an existing effective vaccine, hepatitis B virus (HBV) remains a major public health concern. There are effective suppressive therapies for HBV, but they remain expensive and inaccessible to… Expand
Rapid host immune response and viral dynamics in herpes simplex virus-2 infection
Herpes simplex virus-2 (HSV-2) is periodically shed throughout the human genital tract. Although a high viral load correlates with the development of genital ulcers, shedding also commonly occurs… Expand
Timing and severity of community acquired respiratory virus infections after myeloablative versus non-myeloablative hematopoietic stem cell transplantation
- Joshua T. Schiffer, K. Kirby, B. Sandmaier, R. Storb, L. Corey, M. Boeckh
- 1 August 2009
Respiratory virus infections are important causes of morbidity and mortality after hematopoietic cell transplantation. Their clinical course can be severe with progression to lower respiratory tract… Expand
HSV-2 serology can be predictive of HIV epidemic potential and hidden sexual risk behavior in the Middle East and North Africa.
BACKGROUND HIV prevalence is low in the Middle East and North Africa (MENA) region, though the risk or potential for further spread in the future is not well understood. Behavioral surveys are… Expand
Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
BACKGROUND Skin and mucosal herpes simplex virus type 2 (HSV-2) shedding predominantly occurs in short subclinical episodes. We assessed whether standard-dose or high-dose antiviral therapy reduces… Expand
Plasma and cerebrospinal fluid herpes simplex virus levels at diagnosis and outcome of neonatal infection.
OBJECTIVE To evaluate the utility of quantitative herpes simplex virus (HSV) polymerase chain reaction (PCR) levels for prognosis and management of neonatal HSV disease. STUDY DESIGN Clinical and… Expand
Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis
- K. J. Looker, Jocelyn Elmes, +4 authors Marie-Claude Boily
- The Lancet. Infectious diseases
- 1 December 2017
Summary Background HIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial global disease burden and are epidemiologically correlated. Two previous systematic reviews of the… Expand
Rapid and Profound Shifts in the Vaginal Microbiota Following Antibiotic Treatment for Bacterial Vaginosis.
- B. Mayer, S. Srinivasan, T. Fiedler, J. Marrazzo, D. Fredricks, Joshua T. Schiffer
- The Journal of infectious diseases
- 12 February 2015
BACKGROUND Bacterial vaginosis (BV) is a common polymicrobial disease associated with numerous negative reproductive health outcomes, including an increased risk of human immunodeficiency virus… Expand
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections
- Joshua T. Schiffer, M. Aubert, Nicholas D. Weber, Esther E. Mintzer, Daniel Stone, K. Jerome
- Biology, Medicine
- Journal of Virology
- 20 June 2012
ABSTRACT Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies target only replicating… Expand
The cumulative burden of double-stranded DNA virus detection after allogeneic HCT is associated with increased mortality.
Strategies to prevent active infection with certain double-stranded DNA (dsDNA) viruses after allogeneic hematopoietic cell transplantation (HCT) are limited by incomplete understanding of their… Expand