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Speed-dependent automatic zooming couples the user's rate of motion through an information space with the zoom level—the faster the user moves the 'higher' they fly above the work surface. Igarashi and Hinckley [2000] proposed using the technique to improve scrolling through large documents. Their informal preliminary evaluation showed mixed results with(More)
Previous studies indicate that user performance with scrolling can be improved through Speed-Dependent Automatic Zooming (SDAZ), which automatically couples the document's zoom-level with scroll-speed. These studies have compared traditional scrolling techniques (scrollbars and rate-based scrolling) with SDAZ, leaving a potential confound that the(More)
Speed dependent automatic zooming (SDAZ) is a promising refinement to scrolling in which documents are automatically zoomed-out as the scroll rate increases. By automatically zooming, the visual flow rate is reduced enabling rapid scrolling without motion blur. In order to aid SDAZ calibration we theoretically and empirically scrutinise human factors of the(More)
OBJECTIVE Mitochondrial [Ca2+] ([Ca2+]m) rises in parallel with cytosolic [Ca2+] ([Ca2+]c) following ATP-depletion rigor contracture induced by hypoxia in isolated cardiomyocytes. We investigated the pathways involved in the hypoxia induced changes in [Ca2+]m by using known inhibitors of mitochondrial Ca2+ transport, namely ruthenium red, an inhibitor of(More)
Platelet secretion not only drives thrombosis and hemostasis, but also mediates a variety of other physiological and pathological processes. The ubiquitous SNARE machinery and a number of accessory proteins have been implicated in regulating secretion in platelet. Although several platelet SNAREs have been identified, further members of the SNARE family may(More)
Speed-dependent automatic zooming (SDAZ) interfaces allow rapid navigation through large visual information spaces by automatically zooming out when the user moves quickly through the dataspace. We have implemented a variety of SDAZ interfaces that provide compelling map-based demonstrations of the technique. In particular, our 'globe browser' demonstrates(More)
Rho GTPases such as Rac, RhoA, and Cdc42 are vital for normal platelet function, but the role of RhoG in platelets has not been studied. In other cells, RhoG orchestrates processes integral to platelet function, including actin cytoskeletal rearrangement and membrane trafficking. We therefore hypothesized that RhoG would play a critical role in platelets.(More)
BACKGROUND Formation of filopodia and other shape change events are vital for platelet hemostatic function. The mechanisms regulating filopodia formation by platelets are incompletely understood however. In particular the small GTPase responsible for initiating filopodia formation by platelets remains elusive. The canonical pathway involving Cdc42 is not(More)
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