Joshua J. Ofman

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OBJECTIVE To systematically evaluate the published evidence regarding the characteristics and effectiveness of disease management programmes. DESIGN Meta-analysis. DATA SOURCES Computerised databases for English language articles during 1987-2001. STUDY SELECTION 102 articles evaluating 118 disease management programmes. MAIN OUTCOME MEASURES Pooled(More)
OBJECTIVE The authors systematically evaluated the published evidence to assess the effectiveness of disease management programs in depression. METHOD English-language articles on depression were identified through a MEDLINE search for the period from January 1987 to June 2001. Two reviewers evaluated 16,952 published titles, identified 24 depression(More)
OBJECTIVE Prior metaanalyses of the risk of upper gastrointestinal (GI) complications associated with nonsteroidal antiinflammatory drugs (NSAID) have focused on the published English language epidemiologic literature and/or only a portion of the relevant evidence, restrictions that are now known to be associated with bias in metaanalysis. We synthesized(More)
OBJECTIVE To systematically evaluate and synthesize published evidence regarding the effect of disease management programs for patients with diabetes mellitus on processes and outcomes of care. STUDY DESIGN Systematic literature review and meta-analysis. PATIENTS AND METHODS Computerized databases were searched for English-language controlled studies(More)
OBJECTIVE To examine the increasing use of health economic studies and practical implications of evaluating their quality utilizing the Quality of Health Economic Studies (QHES) instrument. METHODS We first reviewed secondary references to examine ways in which health economic analyses are used in different health care settings, the manner in which these(More)
PURPOSE To assess the clinical and economic effects of disease management in patients with chronic diseases. METHODS Electronic databases were searched for English-language articles from 1987 to 2001. Articles were included if they used a systematic approach to care and evaluated patients with chronic disease, reported objective measurements of the(More)
One-third of adults experience pain or discomfort in the upper abdomen during a given year.1 Of these, 1/4 seek treatment, making dyspepsia the presenting complaint of 4% of patients visiting primary care physicians.2,3 The optimal approach to uncomplicated dyspepsia in this setting remains controversial. Previous guidelines recommended initial(More)
BACKGROUND:Azathioprine (AZA) is effective for the maintenance of a steroid free remission in Crohn's disease (CD). Thiopurine methyltransferase (TPMT) is important for the metabolism of AZA and influences the production of active AZA metabolites. AZA dose selection based on pharmacogenetic testing of TPMT and metabolite monitoring (MM) may offer a safety(More)
OBJECTIVE:Several noninvasive methods are now available for diagnosing Helicobacter pylori infection. Because the prevalence of H. pylori infection is variable in patients requiring testing, the optimal testing strategies may vary under different conditions. The aim of this study was to evaluate the cost-effectiveness of competing diagnostic strategies for(More)
BACKGROUND & AIMS Evaluation of new patients with noncardiac chest pain (NCCP) may require a variety of costly tests. The aim of this study was to evaluate the efficacy of the omeprazole test (OT) in diagnosing gastroesophageal reflux (GERD) in patients with NCCP and estimate the potential cost savings of this strategy compared with conventional diagnostic(More)