Joshua Foxson

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Antagonists of myosin light chain (MLC) kinase (MLCK) and Rho kinase (ROK) are thought to inhibit hypoxic pulmonary vasoconstriction (HPV) by decreasing the concentration of phosphorylated MLC at any intracellular Ca(2+) concentration ([Ca(2+)](i)) in pulmonary arterial smooth muscle cells (PASMC); however, these antagonists can also decrease [Ca(2+)](i).(More)
Previous studies indicated that acute hypoxia increased intracellular Ca(2+) concentration ([Ca(2+)](i)), Ca(2+) influx, and capacitative Ca(2+) entry (CCE) through store-operated Ca(2+) channels (SOCC) in smooth muscle cells from distal pulmonary arteries (PASMC), which are thought to be a major locus of hypoxic pulmonary vasoconstriction (HPV). Moreover,(More)
Wang J, Weigand L, Foxson J, Shimoda LA, Sylvester JT. Ca signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists. Am J Physiol Lung Cell Mol Physiol 293: L674–L685, 2007. First published June 15, 2007; doi:10.1152/ajplung.00141.2007.—Antagonists of myosin light chain (MLC) kinase (MLCK) and Rho kinase (ROK)(More)
Weigand, Letitia, Joshua Foxson, Jian Wang, Larissa A. Shimoda, and J. T. Sylvester. Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca and nonselective cation channels. Am J Physiol Lung Cell Mol Physiol 289: L5–L13, 2005. First published February 18, 2005; doi:10.1152/ajplung.00044.2005.—Previous studies indicated that(More)
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