Joshua F. Apgar

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The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Summary Computational models are increasingly used to understand and predict complex biological phenomena. These models contain many unknown parameters, at least some of which are difficult to measure directly, and instead are estimated by(More)
Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. One challenge in model development is that, with limited experimental data, multiple models can be consistent with known mechanisms(More)
Computational models are increasingly used to understand and predict complex biological phenomena. These models contain many unknown parameters, at least some of which are difficult to measure directly, and instead are estimated by fitting to time-course data. Previous work has suggested that even with precise data sets, many parameters are unknowable by(More)
The ORCA-IX is a fully autonomous submarine built to compete in the 2006 International AUV Competition. The ORCA-IX is 1.27 m long, and masses approximately 45 kg. The vehicle is propelled by a pair of thrusters mounted horizontally on the sides and a pair of thrusters mounted vertically on the bow and stern. The autonomous operation of the vehicle is made(More)
The ORCA-VIII is a fully autonomous submarine built to compete in the 2005 International AUV Competition. The ORCA-VIII is 1.27 m long, 0.711 m wide, 0.457 m deep, and masses approximately 45 kg. The vehicle is propelled by a pair of horizontal thrusters mounted on the sides and a pair of vertical thrusters on the bow and stern. Autonomous navigation is(More)
The ORCA-VII is a fully autonomous submarine built to compete in the 2004 International AUV competition. The ORCA-VII is 48" long, 28" wide, and approximately 45 kg. The vehicle is propelled by a pair of horizontal thrusters mounted on the sides and a pair of vertical thrusters on the bow and stern. Autonomous navigation is aided by a suite of instruments(More)
Inhibition of the IGF1R, INSRA, and INSRB receptor tyrosine kinases represents an attractive approach of pharmacologic intervention in cancer, owing to the roles of the IGF1R and INSRA in promoting cell proliferation and survival. However, the central role of the INSRB isoform in glucose homeostasis suggests that prolonged inhibition of this kinase could(More)
2735 Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System Karen E. Parrish, Ling Cen, James Murray, David Calligaris, Sani Kizilbash, Rajendar K. Mittapalli, Brett L. Carlson, Mark A. Schroeder, Julieann Sludden, Alan V. Boddy, Nathalie Y.R. Agar, Nicola J.(More)
Antibody drug conjugates (ADCs) are promising therapies currently in development for oncology with unique and challenging regulatory and scientific considerations. While there are currently no regulatory guidelines specific for the nonclinical development of ADCs, there are harmonized international guidelines (e.g., ICHS6(R1), ICHM3(R2), ICHS9) that apply(More)
Inhibition of the IGF1R, INSRA, and INSRB receptor tyrosine kinases represents an attractive approach of pharmacologic intervention in cancer, owing to the roles of the IGF1R and INSRA in promoting cell proliferation and survival. However, the central role of the INSRB isoform in glucose homeostasis suggests that prolonged inhibition of this kinase could(More)
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