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As computers and other information technology move into cars and trucks, distraction-related crashes are likely to become an important problem. This paper begins to address this problem by examining how alert strategy (graded and single-stage) and alert modality (haptic and auditory) affect how well collision warning systems mitigate distraction and direct(More)
  • Deqiong Ma, Daria Salyakina, James M Jaworski, Ioanna Konidari, Patrice L Whitehead, Ashley N Andersen +15 others
  • 2009
Although autism is one of the most heritable neuropsychiatric disorders, its underlying genetic architecture has largely eluded description. To comprehensively examine the hypothesis that common variation is important in autism, we performed a genome-wide association study (GWAS) using a discovery dataset of 438 autistic Caucasian families and the Illumina(More)
OBJECTIVE The aim of this study was to assess how scrolling through playlists on an MP3 player or its aftermarket controller affects driving performance and to examine how drivers adapt device use to driving demands. BACKGROUND Drivers use increasingly complex infotainment devices that can undermine driving performance. The goal activation hypothesis(More)
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and(More)
Emerging in-vehicle technology associated with radio data systems (RDS), satellite radio, navigation aids, and infotainment systems will expose drivers to an increasing amount of textual information. The visual demands of driving make it critically important to understand how characteristics of such information affect visual sampling of the roadway. This(More)
OBJECTIVE In this study, we investigated how drivers adapt secondary-task initiation and time-sharing behavior when faced with fluctuating driving demands. BACKGROUND Reading text while driving is particularly detrimental; however, in real-world driving, drivers actively decide when to perform the task. METHOD In a test track experiment, participants(More)
Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these(More)
PURPOSE Age-related macular degeneration is a common form of vision loss affecting older adults. The etiology of AMD is multifactorial and is influenced by environmental and genetic risk factors. In this study, we examine how 19 common risk variants contribute to drusen progression, a hallmark of AMD pathogenesis. METHODS Exome chip data was made(More)