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As computers and other information technology move into cars and trucks, distraction-related crashes are likely to become an important problem. This paper begins to address this problem by examining how alert strategy (graded and single-stage) and alert modality (haptic and auditory) affect how well collision warning systems mitigate distraction and direct(More)
Although autism is one of the most heritable neuropsychiatric disorders, its underlying genetic architecture has largely eluded description. To comprehensively examine the hypothesis that common variation is important in autism, we performed a genome-wide association study (GWAS) using a discovery dataset of 438 autistic Caucasian families and the Illumina(More)
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, mostly rare, protein-altering variants. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and(More)
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OBJECTIVE The aim of this study was to assess how scrolling through playlists on an MP3 player or its aftermarket controller affects driving performance and to examine how drivers adapt device use to driving demands. BACKGROUND Drivers use increasingly complex infotainment devices that can undermine driving performance. The goal activation hypothesis(More)
Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10 % of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45 % and 70 %. Numerous variants have been identified and implicate various molecular(More)
Emerging in-vehicle technology associated with radio data systems (RDS), satellite radio, navigation aids, and infotainment systems will expose drivers to an increasing amount of textual information. The visual demands of driving make it critically important to understand how characteristics of such information affect visual sampling of the roadway. This(More)
PURPOSE Age-related macular degeneration is the leading cause of blindness among the adult population in the developed world. To further the understanding of this disease, we have studied the genetically isolated Amish population of Ohio and Indiana. METHODS Cumulative genetic risk scores were calculated using the 19 known allelic associations. Exome(More)
  • Michael P Linegang, Heather A Stoner, Michael J Patterson, Bobbie D Seppelt, Joshua D Hoffman, Zachariah B Crittendon +1 other
  • 2006
The US Navy is funding the development of advanced automation systems to plan and execute unmanned vehicles missions, pushing towards a higher level of autonomy for automated planning systems. With effective systems, the human could play a role of mission manager and automation systems could perform mission planning and execution tasks with limited human(More)