Joshua C. T. Khoo

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Incubation of mouse peritoneal macrophages with native human low density lipoprotein (LDL) did not cause any significant storage of intracellular cholesteryl esters. However, when the LDL was subjected to brief (30-second) vortexing, it formed self-aggregates that were rapidly ingested and degraded by macrophages, converting them to cholesteryl ester-rich(More)
Macrophages contain a neutral cholesteryl ester hydrolase that can be activated by cAMP-dependent protein kinase. Immunological studies strongly suggest that hormone-sensitive lipase (HSL) is probably responsible for the cholesteryl ester hydrolase activity in macrophages; however, due to the very low level of expression in macrophages, it has been(More)
We have shown previously that low density lipoprotein (LDL) subjected to vortexing forms self-aggregates that are avidly phagocytosed by macrophages. That phagocytic uptake is mediated by the LDL receptor. We now show that LDL self-aggregation is strongly inhibited (80-95%) by the presence of high density lipoprotein (HDL) or apolipoprotein (apo) A-I.(More)
  • Y L Theng, D H L Goh, Na, J C Khoo, P H J Halim, Lek +14 others
  • 2006
There is a serious lack of conceptual clarity of definitions and uses of learning objects, resulting in design and usability problems in current e-learning systems. The paper proposes ReLOMS, prototype reusable learning objects management system, being implemented to address the problem of usability and reusability of learning objects in e-learning systems.(More)
For this style citations are listed alphabetically, but are cited in the text using name and year format. (2001). What makes a problem gp-hard? analysis of tunably difficult problems in genetic programming. the influence of depth and degree of genotypic change on fitness in genetic programming.
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