Joshua Atkins

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Flecainide (pKa 9.3, 99% charged at pH 7.4) and lidocaine (pKa 7.6-8.0, approximately 50% neutral at pH 7.4) have similar structures but markedly different effects on Na(+) channel activity. Both drugs cause well-characterized use-dependent block (UDB) of Na(+) channels due to stabilization of the inactivated state, but flecainide requires that channels(More)
Flecainide (pKa 9.3, 99% charged at pH 7.4) and lidocaine (pKa 7.6–8.0, 50% neutral at pH 7.4) have similar structures but markedly different effects on Na channel activity. Both drugs cause well-characterized use-dependent block (UDB) of Na channels due to stabilization of the inactivated state, but flecainide requires that channels first open before block(More)
BACKGROUND Accurate monitoring of respiratory rate may be useful for the early detection of patient deterioration. Monitoring of respiratory rate in the operating room under general anesthesia by spirometry is technically straightforward and demonstrates high fidelity. Accurate measurement of the respiratory rate of an unattended patient outside the(More)
Spherical microphone and loudspeaker arrays present a compact method for analysis and synthesis of arbitrary three-dimensional sound fields. However, issues such as sensor self noise, placement errors, and mismatch require robustness constraints in beamformer design. This work presents a method for designing robust beam patterns with an arbitrary shape and(More)
Significant fluctuations in serum glucose levels accompany the stress response of surgery or acute injury and may be associated with vascular or neurologic morbidity. Maintenance of euglycemia with intensive insulin therapy (IIT) continues to be investigated as a therapeutic intervention to decrease morbidity associated with derangements in glucose(More)
STUDY OBJECTIVE To characterize respiratory dynamics during emergence from propofol-remifentanil anesthesia using noninvasive respiratory inductance plethysmography (RIP). DESIGN Observational pilot study. SETTING Operating room in a university-affiliated teaching hospital. PATIENTS 50 ASA physical status 1, 2, and 3 patients scheduled for microdirect(More)
  • Joshua Atkins
  • 2010 IEEE International Conference on Acoustics…
  • 2010
The design of spherical loudspeaker arrays involves the discrete sampling of the sphere. In practical applications the desired number of sample points is very low (possibly 16–32 transducers) and there are typically one or more areas in the room that cannot accommodate loudspeakers. This paper presents an optimization method for choosing loudspeaker(More)