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OBJECTIVES To assess changes in regional brain volumes associated with the fragile X-associated tremor/ataxia syndrome (FXTAS) and the molecular correlates of these changes. METHODS We administered molecular, MRI, and neurocognitive tests to 36 male premutation carriers (ages 51 to 79), 25 affected and 11 unaffected with FXTAS, and to 21 control subjects(More)
BACKGROUND It is widely agreed that species are fundamental units of biology, but there is little agreement on a definition of species or on an operational criterion for delimiting species that is applicable to all organisms. METHODOLOGY/PRINCIPAL FINDINGS We focus on asexual eukaryotes as the simplest case for investigating species and speciation. We(More)
We report on the observation of two neutrino-induced events which have an estimated deposited energy in the IceCube detector of 1.04±0.16 and 1.14±0.17 PeV, respectively, the highest neutrino energies observed so far. These events are consistent with fully contained particle showers induced by neutral-current ν(e,μ,τ) (ν(e,μ,τ)) or charged-current ν(e)(More)
We present the results of time-integrated searches for astrophysical neutrino sources in both the northern and southern skies. Data were collected using the partially-completed IceCube detector in the 40-string configuration recorded maximum likelihood ratio method is used to search for astrophysical signals. The data sample contains 36,900 events: 14,121(More)
BACKGROUND AND PURPOSE The proteasome inhibitor PS-519 blocks activation of nuclear factor-kappaB, a major mediator of inflammation. We tested the hypothesis that combination treatment of recombinant human tissue plasminogen activator (rhtPA) and PS-519 extends the therapeutic window for treatment of stroke with rhtPA without increasing incidence of(More)
It is valuable to identify and catalog design patterns for reconfigurable computing. These design patterns are canonical solutions to common and recurring design challenges which arise in reconfigurable systems and applications. The catalog can form the basis for creating designs, for educating new designers, for understanding the needs of tools and(More)
3 Abstract The first sensors of the IceCube neutrino observatory were deployed at the South Pole during the austral summer of 2004-05 and have been producing data since February 2005. One string of 60 sensors buried in the ice and a surface array of 8 ice Cherenkov tanks took data until December 2005 when deployment of the next set of strings and tanks(More)