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Proteolytically activated receptors (PARs) represent an emerging subset of seven transmembrane G protein-coupled receptors that mediate cell activation events by receptor cleavage at distinct scissile bonds located within receptor amino termini. Differential genomic blotting using a yeast artificial chromosome known to contain the PAR-1 and PAR-2 genes(More)
Models that predict the soft tissue deformation caused by needle insertion could improve the accuracy of procedures such as brachytherapy and needle biopsy. Prior work on needle insertion modeling has focused on static deformation; the experiments presented here show dynamic effects such as relaxation are important. An experimental setup is described for(More)
ST-Guide is a computer-interpretable clinical guidelines development, verification, and implementation project focused on primary care to chronic disease patients. It can be used to implement guides in different modes: authoritarian, apprentice, specialist, and auditor. Only specialist and authoritarian modes are functional in this release. This paper(More)
The progressive stabilization of fibrinogen binding to ADP-treated platelets has been well described, but the nature of this interaction remains obscure. In the present study, irreversibly bound fibrinogen was defined as that fraction of bound iodinated fibrinogen that failed to dissociate from stimulated human gel-filtered platelets within 10 min of adding(More)
Human blood platelets function in wound healing, inflammation, and clot formation. Despite significant progress molecular mechanisms of megakaryocyte maturation remain poorly characterized. We have applied a customized, platelet-specific oligonucleotide gene chip to dissect the molecular events of megakaryopoiesis. CD34 hematopoietic stem cells obtained(More)
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