Josh Rabinowitz

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Steady-state metabolite concentrations in a microorganism typically span several orders of magnitude. The underlying principles governing these concentrations remain poorly understood. Here, we hypothesize that observed variation can be explained in terms of a compromise between factors that favor minimizing metabolite pool sizes (e.g. limited solvent(More)
  • W T Peake, Keithley A H, Crist Prof W M Siebert, N Y S Kiang, Kava T F Prof, W M Weiss +22 others
  • 2009
In cooperation with the Eaton-Peabody Laboratory at the Massachusetts Eye and Ear Infirmary we have continued our work toward understanding the auditory system and applying this basic knowledge to clinical problems. Experimental studies of the mechanical system of the inner ear, which have been carried out in several laboratories in recent years, have(More)
We discuss the physicochemical basis for mechanisms of action of toxic chemicals and theoretical methods that can be used to understand the relation to the structure of these chemicals. Molecular properties that determine the chemical reactivity of the compounds are proposed as parameters in the analysis of such structure-activity relationships and as(More)
The kinetics of acid release by a mixture of T cells and antigen presenting cells were measured with a microphysiometer during a brief exposure to antigenic peptides. We find that some of the early biochemical events that lead to cellular proliferation cause a specific increase in the rate of acid release. The duration of this increase in acid release(More)
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