Josh Leighton

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
The biology of animal cells in culture is often studied in individual cells or in sheets of cells. The relevance of such studies to the intact animal is unclear, since the spatial conditions encountered by cells in animals is one of dense three-dimensional masses of cells, with limits to migration, and with gradients both of diffusion of metabolites and of(More)
  • J Leighton
  • 1997
A system has been developed for the culture of cells that provides conditions favoring the formation of tissues comparable to conditions existing in nature. The culture chamber is a lens-shaped pouch composed of two thin-walled, reinforced, waffled collagen membranes facing each other. The chamber is immersed in medium in a closed transparent container and(More)
  • J Leighton
  • 1991
Histophysiologic gradient culture methods reconstitute important spatial relationships that occur in nature between a parenchyma and its supporting stroma. At the epithelial-stromal interface, epithelia are firmly attached to the stromal substrate, initiation of renewal takes place, and metabolites are exchanged by a process of diffusion between epithelium(More)
  • J Leighton
  • 1992
Epithelial cells proliferate, forming organized tissues, when positioned in the lumen of a thin-walled, transparent, elongated cylindrical, cystlike culture chamber. The closed chamber, 2.5 mm in diameter and 25 mm long, bathed in medium, incubated with continuous gentle agitation, enables the inoculum to exchange metabolites including oxygen by diffusion(More)
We consider the problem of maximizing underwater acoustic data transmission by adaptively positioning an autonomous mobile relay so as to learn and exploit spatial variations in channel performance. The acoustic channel is the main practical method of underwater wireless communication and improving channel throughput and reliability is key to improving the(More)
  • 1