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Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain-Barré syndrome and fetal abnormalities, but the underlying mechanisms remain poorly understood. Animal models of infection are thus urgently needed. Here we show that rhesus macaques are susceptible to infection by an Asian-lineage ZIKV closely related to strains currently(More)
A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitness in the context of the cognate transmitted/founder (T/F) genome, we developed a new(More)
UNLABELLED Infants born to HIV-1-infected mothers in resource-limited areas where replacement feeding is unsafe and impractical are repeatedly exposed to HIV-1 throughout breastfeeding. Despite this, the majority of infants do not contract HIV-1 postnatally, even in the absence of maternal antiretroviral therapy. This suggests that immune factors in breast(More)
BACKGROUND Zika virus (ZIKV; Flaviviridae, Flavivirus) was declared a public health emergency of international concern by the World Health Organization (WHO) in February 2016, because of the evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome in adults and congenital birth defects including microcephaly in the(More)
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was(More)
18 syndrome and fetal microcephaly 1-4. Here we show that rhesus macaques are susceptible 19 to infection by an Asian lineage Zika virus isolate that shares more than 99% nucleotide 20 identity with strains currently circulating in the Americas. Following subcutaneous 21 inoculation, Zika virus RNA was detected in plasma one-day post infection (dpi) in all(More)
19 syndrome and fetal abnormalities 1-4 , but the mechanisms and risk factors for these 20 outcomes remain unknown. Here we show that rhesus macaques are susceptible to 21 infection by an Asian-lineage virus closely related to strains currently circulating in the 22 Americas. Following subcutaneous inoculation, Zika virus RNA was detected in plasma 23 one(More)
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