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Pharmacokinetics, Safety, and Tolerability of Oral Posaconazole Administered in Single and Multiple Doses in Healthy Adults
ABSTRACT The pharmacokinetics, safety, and tolerability of posaconazole, an investigational triazole antifungal, were evaluated following the administration of rising single and multiple oral doses.Expand
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Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults.
AIMS This randomized, crossover, single-dose study evaluated the relative oral bioavailability of posaconazole suspension and coprecipitate tablet formulations. Additionally, the study determinedExpand
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Oral Bioavailability of Posaconazole in Fasted Healthy Subjects
Background and objectivePosaconazole is a potent, extended-spectrum triazole antifungal agent currently in clinical development for the treatment of invasive fungal infections. This study wasExpand
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Pharmacokinetics of Posaconazole Coadministered with Antacid in Fasting or Nonfasting Healthy Men
ABSTRACT Posaconazole is a potent broad-spectrum azole antifungal agent in clinical development for the treatment of invasive fungal infections. This study evaluated the potential for a pH-dependentExpand
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Grapefruit Juice Reduces the Oral Bioavailability of Fexofenadine But Not Desloratadine
BackgroundCertain foods, such as grapefruit juice, are known to substantially alter the bioavailability of some drugs. These effects may be mediated by interactions with enzyme systems, such asExpand
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The pharmacokinetics of ceftibuten in humans.
The pharmacokinetics of ceftibuten, a new oral cephalosporin, has been studied in humans. Ceftibuten is very well absorbed in young and old patients. Absorption may be slightly decreased by food orExpand
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Use of high-performance liquid chromatographic and microbiological analyses for evaluating the presence or absence of active metabolites of the antifungal posaconazole in human plasma.
Posaconazole (SCH 56592) is a novel broad spectrum triazole antifungal agent that is currently in phase III clinical trials for the treatment of systemic fungal infections. This study was initiatedExpand
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Investigating the influence of total electrolyte concentration and sodium–calcium ion competition on controlled dispersion of swelling clays
Abstract The influence of clay dispersion method on dewatering behaviour of a run-of-mine bentonite was examined to better understand the roles of calcium–sodium ion exchange and overall electrolyteExpand
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Captopril in congestive heart failure resistant to other vasodilators.
In an attempt to study the possible mechanism(s) by which captopril controls resistant heart failure, sequential haemodynamic studies (radioisotope technique) and humoral measurements (plasma reninExpand
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Effect of Felbamate on the Pharmacokinetics of Lamotrigine
To assess the possible interaction between lamotrigine and felbamate, a double‐blind, randomized, placebo‐controlled, two‐way crossover study was conducted in 21 healthy male volunteers. VolunteersExpand
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