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This study examined in baboons various behavioral effects of zolpidem, a short-acting imidazopyridine hypnotic which has selectivity for subtypes of the benzodiazepine receptor. Intravenous drug self-injection was studied under a fixed-ratio 80- or 160-response schedule with a 3-hr timeout after each injection. Maximal rates of self-injection maintained by(More)
Responding maintained under progressive ratio (PR) and fixed ratio (FR 160) schedules of IV saline or cocaine (0.01–4.0 mg/kg) injections was studied in baboons. Each injection was followed by a time-out period which was 3-h with the PR schedule and was either 3 or 12 h with the FR schedule. On the PR schedule the ratio requirement was systematically(More)
Cocaine, methylphenidate and secobarbital were compared on a drug maintained progressive-ratio procedure in baboon subjects. Trials, scheduled throughout the day, occurred at a minimum interval of 3 hrs after completion of the preceding trial. A ratio response requirement on the “initiate” lever was required during each trial which terminated in a single(More)
Cocaine, diethylpropion, chlorphentermine, and fenfluramine were compared on a drug-maintained progressive-ratio procedure in baboons. Intravenous infusions of drug were contingent on completion of a fixed-ratio response requirement (fixed number of lever-press responses) with a 3-h time-out period following each infusion. Prior to testing each dose of(More)
A system for minimally restraining adult baboons with chronic intravenous (IV) or intragastric (IG) catheters for long term pharmacological and behavioral studies is described. The system consists of an adjustable foam-padded backplate and harness which is custom-fitted to each animal. A flexible stainless-steel cable connects the backplate to a liquid(More)
The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions(More)
Nine male research volunteers, in three groups of three subjects each, resided in a residential laboratory for up to 25 days. All contact with the experimenter was through a networked computer system and subjects' behaviors including food intake were continuously recorded. Subjects brought their own activities such as model-making, and these in combination(More)
Three adult male baboons were trained on a psychophysical procedure to discriminate five synthetic, steady-state vowel sounds [a), (ae), (c), (U), and (epsilon] from one another. A pulsed train of one vowel comprised the reference stimulus during a session. Animals were trained to press a lever and release the lever only when this reference vowel sound(More)
Eight opioid agonist, mixed agonist/antagonist or antagonist compounds were compared in baboons. In the first experiment, i.v. drug self-injection procedures involved a fixed-ratio schedule with a 3 hr time-out after each injection. Doses of a test drug were substituted for cocaine for 12 or 15 days. Codeine, morphine, butorphanol, nalbuphine and(More)