Joseph V. Bonventre

Takaharu Ichimura7
Craig R. Brooks4
7Takaharu Ichimura
4Craig R. Brooks
3Ryuji Morizane
3Venkata Sabbisetti
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Vascular inflammation is a major contributor to the severity of acute kidney injury. In the context of vasospasm-independent reperfusion injury we studied the potential anti-inflammatory role of the Gα-related RGS protein, RGS4. Transgenic RGS4 mice were resistant to 25 min injury, although post-ischemic renal arteriolar diameter was equal to the wild type(More)
Neuronal expression of familial Alzheimer's disease-mutant human amyloid precursor protein (hAPP) and hAPP-derived amyloid-beta (Abeta) peptides causes synaptic dysfunction, inflammation and abnormal cerebrovascular tone in transgenic mice. Fatty acids may be involved in these processes, but their contribution to Alzheimer's disease pathogenesis is(More)
  • Vishal S. Vaidya, Josef S. Ozer, Dieterle Frank, Fitz B. Collings, Victoria Ramirez, Sean Troth +13 others
  • 2010
0 drenal Gland Ankle Joint adder Urinary Blood Cells essels (Aorta) Bone (Femur) arrow (Femur) ain Amygdala Cortex Frontal Hippocampus Hypothalamus Cartilage Cecum Colon Duodenum ipose Tissue) Fat (White) Heart Apex Ileum Jejunum Kidney ney (Cortex) ey (Medulla) Liver Lung Lymph Nodes scle (Skeletal) erve (Sciatic) Ovary uitary (Gland) Renal Artery Skin(More)
Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses in(More)
  • Ivica Grgic, Gabriela Campanholle, Vanesa Bijol, Chang Wang, Venkata S. Sabbisetti, Takaharu Ichimura +2 others
  • 2012
Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target various kidney cell types including(More)
We examined brain phospholipid metabolism in mice in which the cytosolic phospholipase A(2) (cPLA(2,) Type IV, 85 kDa) was knocked out (cPLA(2)(-/-) mice). Compared with controls, these mice demonstrated altered brain concentrations of several phospholipids, reduced esterified linoleate, arachidonate, and docosahexaenoate in choline glycerophospholipid, and(More)
Pre-renal acute kidney injury (AKI) is assumed to represent a physiological response to underperfusion. Its diagnosis is retrospective after a transient rise in plasma creatinine, usually associated with evidence of altered tubular transport, particularly that of sodium. In order to test whether pre-renal AKI is reversible because injury is less severe than(More)
Ion channels reside in a sea of phospholipids. During normal fluctuations in membrane potential and periods of modulation, lipids that directly associate with channel proteins influence gating by incompletely understood mechanisms. In one model, M(1)-muscarinic receptors (M(1)Rs) may inhibit both Ca(2+) (L- and N-) and K(+) (M-) currents by losing a(More)
  • Monika A Niewczas, Tammy L Sirich, Anna V Mathew, Jan Skupien, Robert P Mohney, James H Warram +11 others
  • 2014
Here we studied plasma metabolomic profiles as determinants of progression to end-stage renal disease (ESRD) in patients with type 2 diabetes (T2D). This nested case-control study evaluated 40 cases who progressed to ESRD during 8-12 years of follow-up and 40 controls who remained alive without ESRD from the Joslin Kidney Study cohort. Controls were matched(More)
Resident tissue macrophages are activated by the fungal pathogen Candida albicans to release eicosanoids, which are important modulators of inflammation and immune responses. Our objective was to identify the macrophage receptors engaged by C. albicans that mediate activation of group IVA cytosolic phospholipase A(2) (cPLA(2)α), a regulatory enzyme that(More)