Joseph Usset

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Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogenous biospecimens offer a promising solution, however the performance of such methods(More)
Five rapid visual stream assessment methods were applied to 65 restored streams in North Carolina, and the results were correlated with measured macroinvertebrate community metrics to evaluate predictive ability. The USEPA Rapid Bioassessment Protocol (RBP), USDA Stream Visual Assessment Protocol (SVAP), Peterson’s Riparian Channel and Environmental(More)
BACKGROUND Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure and elevated estrogen levels are associated with obesity in postmenopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-related risk factors could differ between obese and non-obese women. METHODS We considered interactions(More)
A functional regression model with a scalar response and multiple functional predictors is proposed that accommodates two-way interactions in addition to their main effects. The proposed estimation procedure models the main effects using penalized regression splines, and the interaction effect by a tensor product basis. Extensions to generalized linear(More)
Mountain glacier retreat is an important problem related to temperature increase caused by global climate change. The retreat of mountain glaciers has been studied from the ground, but there exists a need for automated methods to catalog glacial change with a wider scope. A viable approach is to extract intensity profiles from Landsat images along the(More)
Background: The peripheral blood neutrophil-to-lymphocyte ratio (NLR) is a cytologic marker of both inflammation and poor outcomes in patients with cancer. DNA methylation is a key element of the epigenetic program defining different leukocyte subtypes and may provide an alternative to cytology in assessing leukocyte profiles. Our aim was to create a(More)
Restored stream reaches at 79 sites across North Carolina were sampled for aquatic macroinvertebrates using a rapid bioassessment protocol. Morphological design parameters and geographic factors, including watershed and landscape parameters (e.g., valley slope, substrate), were also compiled for these streams. Principal component regression analyses(More)
From March through August 2015, nearly 60 teams from around the world participated in the Prostate Cancer Dream Challenge (PCDC). Participating teams were faced with the task of developing prediction models for patient survival and treatment discontinuation using baseline clinical variables collected on metastatic castrate-resistant prostate cancer (mCRPC)(More)
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