Joseph Terdiman

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Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch repair genes in colorectal cancers,(More)
OBJECTIVE This study assessed the impact of an Internet-delivered care management and patient self-management program, eCare for Moods, on patients treated for recurrent or chronic depression. METHODS Patients with recurrent or chronic depression were randomly assigned to eCare (N=51) or usual specialty mental health care (N=52). The 12-month eCare program(More)
Closed-loop and open-loop optokinetic nystagmus (OKN) eye movements were recorded with an electromagnetic scleral search coil in 16 patients with myasthenic ocular palsies, 8 patients with nonmyasthenic ocular palsies, and 4 normal controls. We calculated the summation of fast-phase amplitude per second (SFPAps), mean of fast-phase amplitude (MFPA) and mean(More)
Adverse reactions to drugs are a major public health care issue. Currently, the Food and Drug Administration (FDA) publishes quarterly reports that typically contain on the order of 200,000 adverse incidents. In such numerous incidents, low frequency events that are clinically highly significant often remain undetected. In this paper, we introduce a visual(More)
Monocular pursuit and saccadic eye movements were compared between a group of 5 men with cerebral palsy and a group of 5 men with normal movements using an infrared corneal reflection technique. Triangle, sine, and square waves (in the time domain) at 0.3 Hz in the horizontal and vertical dimensions were used as the stimuli for six 10-sec. tests of each(More)
BACKGROUND AND PURPOSE Our objective was to examine the agreement between adult patients with stroke and family member or clinician proxies in activity measure for postacute care (AM-PAC) summary scores for daily activity, basic mobility, and applied cognitive function. METHODS This study involved 67 patients with stroke admitted to a hospital within the(More)
BACKGROUND Although colorectal cancer (CRC) screening is widely recommended, screening rates remain low. Workplace interventions have the potential to increase rates of screening. AIMS To evaluate the impact of a workplace CRC screening program targeting active duty and retired firefighters. METHODS A letter, a fecal immunochemical test (FIT) kit and a(More)
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