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This study investigated effects of transcendent experiences on contingent negative variation (CNV) amplitude, CNV rebound, and distraction effects. Three groups of age-matched subjects with few (<1 per year), more frequent (10-20 per year), or daily self-reported transcendent experiences received 31 simple RT trials (flash (S(1))/tone (S(2))/button press)(More)
The present study investigated the reliability of CNV distraction and rebound effects, and their relation with reaction time. Twenty-four subjects were presented three blocks of trials: (1) a control block--a fixed foreperiod reaction time task consisting of a flash-tone-key press sequence; (2) a divided-attention block--randomly intermixed trials with and(More)
The control of computer functions by eye movements was demonstrated in 14 normal volunteers. Electrical potentials recorded by horizontal and vertical electrooculography (EOG) were transformed into a cursor that represented a moving fixation point on a computer display. Subjects were able to spell words and sentences by using eye movements to place the(More)
Twelve male outpatients participating in a methadone maintenance treatment program were evaluated for the effects of acute administration of methadone on brain functioning (contingent negative variation or CNV), attention performance (reaction time and continuous performance test), and psychophysiological activity (heart rate and eye blink rate). Individual(More)
The effects of secobarbital and chlropromazine upon behavior in a continuous, rapidly presented successive (go-no go) discrimination ("attention") task were evaluated in six Macaca mulatta monkeys. Simultaneous monitoring of EEG activity from epidural and subcortical electrodes permitted an evaluation of the nature of altered central nervous system events(More)
Thirty-two normal volunteers were tested in three conditions: (1) a constant-foreperiod reaction-time situation consisting of a flash--tone--key-press sequence (control condition); (2) the addition of a short-term memory task consisting of four letters presented within the flash--tone interval with the requirement that they be repeated after key-press to(More)
Electrical brain activity (contingent negative variation of CNV) and psychomotor behavior (reaction time or RT) were measured after 50 mg of chlorpromazine (CPZ) or placebo were given orally to 28 normal women. CPZ reduced CNV 2 and 3 hrs post-drug and slowed RT 3 hrs post-drug. CNV amplitude appears to be an accurate indicator of drug-produced changes in(More)
The clinical study of ERPs has an inherent defect--a self-selection of clinical populations that hampers equating of clinically defined groups on factors extraneous to the independent variables. Such ex post facto studies increase the likelihood of confounding variables in the interpretation of findings. Hence, the development of lawful relationships(More)