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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
TLDR
It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1alpha, and this finding has strong implications for the basic pathways of energy homeostasis, diabetes and lifespan. Expand
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
TLDR
A mechanism by which a nutrient sensor (mTOR) balances energy metabolism by means of the transcriptional control of mitochondrial oxidative function is identified, which has important implications for the understanding of how these pathways might be altered in metabolic diseases and cancer. Expand
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
TLDR
SIRT1 is identified as a functional regulator of PGC‐1α that induces a metabolic gene transcription program of mitochondrial fatty acid oxidation in response to low glucose concentrations and has implications for understanding selective nutrient adaptation and how it might impact lifespan or metabolic diseases such as obesity and diabetes. Expand
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
TLDR
It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α, and this findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan. Expand
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
TLDR
It is reported that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults, and provides a promising avenue for therapeutic intervention. Expand
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.
TLDR
The endogenous P GC-1alpha protein complex is identified and the molecular mechanism by which PGC-1 alpha acetylation by GCN5 turns off the transcriptional and biological function of this metabolic coactivator is provided. Expand
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
TLDR
It is shown in vivo that hepatic SIRT1 is a factor in systemic and hepatic glucose, lipid, and cholesterol homeostasis and is an important factor in the regulation of glucose and lipid metabolism in response to nutrient deprivation. Expand
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
TLDR
It is proposed that the transition of quiescent stem cells into GAlert functions as an ‘alerting’ mechanism, an adaptive response that positions stem cells to respond rapidly under conditions of injury and stress, priming them for cell cycle entry. Expand
Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction*
TLDR
The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1. Expand
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.
TLDR
Understanding the PGC-1 alpha and SIRT1 pathways might have important implications for comprehending metabolic and age-associated diseases. Expand
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