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Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells.

• Joseph T. Crossno, Susan M. Majka, Todd J. Grazia, Ronald G Gill, Dwight J. Klemm
• The Journal of clinical investigation
• 2006

Obesity and weight gain are characterized by increased adipose tissue mass due to an increase in the size of individual adipocytes and the generation of new adipocytes. New adipocytes are believed to… (More)

Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells.

• Neil J. Davie, Joseph T. Crossno, +7 authors Kurt R Stenmark
• American journal of physiology. Lung cellular and…
• 2004

Information is rapidly emerging regarding the important role of the arterial vasa vasorum in a variety of systemic vascular diseases. In addition, increasing evidence suggests that progenitor cells… (More)

Formation and composition of the Bacillus anthracis endospore.

• Hongbin Liu, Nicholas H. Bergman, +9 authors Philip C Hanna
• Journal of bacteriology
• 2004

The endospores of Bacillus anthracis are the infectious particles of anthrax. Spores are dormant bacterial morphotypes able to withstand harsh environments for decades, which contributes to their… (More)

Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.

• Joseph T. Crossno, Chrystelle V. Garat, +5 authors Dwight J. Klemm
• American journal of physiology. Lung cellular and…
• 2007

Thiazolidinediones (TZDs) are insulin-sensitizing agents that also decrease systemic blood pressure, attenuate the formation of atherosclerotic lesions, and block remodeling of injured arterial… (More)

Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2.

• Keith E Fox, Dana M Fankell, Paul F. Erickson, Susan M. Majka, Joseph T. Crossno, Dwight J. Klemm
• The Journal of biological chemistry
• 2006

The differentiation of preadipocytes to adipocytes is orchestrated by the expression of the "master adipogenic regulators," CCAAT/enhancer-binding protein (C/EBP) beta, peroxisome… (More)

Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.

• Raphael A Nemenoff, Peter A Simpson, +5 authors Mary Weiser-Evans
• Circulation research
• 2008

We previously showed that changes in vascular smooth muscle cell (SMC) PTEN/Akt signaling following vascular injury are associated with increased SMC proliferation and neointima formation. In this… (More)

SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation.

• Raphael A Nemenoff, Henrick N Horita, +6 authors Mary Weiser-Evans
• Arteriosclerosis, thrombosis, and vascular…
• 2011

OBJECTIVE PTEN inactivation selectively in smooth muscle cells (SMC) initiates multiple downstream events driving neointima formation, including SMC cytokine/chemokine production, in particular… (More)

Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells.

• Dwight J. Klemm, Susan M. Majka, Joseph T. Crossno, John C Psilas, Jane E.-B. Reusch, Chrystelle V. Garat
• Journal of cardiovascular pharmacology
• 2011

Hypoxia-induced pulmonary arterial hypertension (PAH) is a deadly disease characterized by progressive remodeling and persistent vasoconstriction of the pulmonary arterial system. Remodeling of the… (More)

Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells.

• Chrystelle V. Garat, Joseph T. Crossno, Timothy M Sullivan, Jane E.-B. Reusch, Dwight J. Klemm
• Journal of cardiovascular pharmacology
• 2013

Hypoxia-induced pulmonary hypertension is characterized by progressive remodeling of the pulmonary artery (PA) system and loss of the transcription factor, cAMP response element binding protein… (More)

Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension.

• Doug Case, David C Irwin, +14 authors Susan K. Majka
• American journal of physiology. Lung cellular and…
• 2007

Pulmonary hypertension (PH) is characterized by sustained vasoconstriction, with subsequent extracellular matrix (ECM) production and smooth muscle cell (SMC) proliferation. Changes in the ECM can… (More)

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