Joseph Shvidler

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OBJECTIVE A new class of carboxylic acids has tumoricidal activity for head and neck squamous cell cancer (HNSCC). Fusaric acid (FA) can chelate divalent cations, especially zinc, and inactivate zinc finger proteins involved in DNA repair and protein synthesis. METHODS 2 squamous carcinoma lines were utilized for in vitro and in vivo portions of this(More)
We report the case of a 48-year-old female who presented to our clinic 8 years after silicone implant forehead augmentation with complaints of brow swelling, tenderness, and periorbital edema. Imaging revealed non-rim enhancing fluid collection and underlying bony ridges. Ensuing medical management included antibiotics which lead to resolution of the(More)
OBJECTIVES To evaluate the effect of mitomycin on the repair of acquired subglottic stenosis and to define the optimal concentration of mitomycin that would minimize restenosis after repair. STUDY DESIGN AND SETTING A randomized prospective model was used in which 20 ferrets (Mustela putorius furo) underwent simulated intubation injury that was then(More)
OBJECTIVE Describe the incidence of head and neck community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections over a 5-year period at a coastal tertiary medical center. STUDY DESIGN Retrospective chart review. SUBJECTS AND METHODS All patients presenting to the otolaryngology service with cultures taken from head and neck(More)
OBJECTIVES We sought to describe the novel use of a suction-irrigation device to remove a large blood clot that was causing critical obstruction of the trachea and main stem bronchi in our patient. METHODS A large-bore suction-irrigation device designed for use in gynecologic cases was adapted for use in removal of an obstructing blood clot in the face of(More)
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