Joseph Santodonato

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Phenol, a monohydroxy derivative of benzene, occurs naturally in animal waste and by decomposition of organic wastes. It is also produced by man, originally by fractional distillation of coal tar, but more recently by cumene hydroperoxidation and toluene oxidation. As a result of large production volume and natural sources, occupational and environmental(More)
Human exposure to nonsteroidal estrogens in the environment has recently been proposed as a risk factor for endocrine disruption and the development of cancers of the breast and reproductive tract. Certain polycyclic aromatic hydrocarbons (PAHs), which closely resemble steroid hormones, are ubiquitous environmental contaminants whose carcinogenicity has(More)
One of the mutagenic byproducts associated with chlorinated humic waters and kraft pulp bleaching effluents was recently identified as 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. This compound and several related chlorofuranones and precursors were synthesized and evaluated for direct-acting mutagenicity in Salmonella typhimurium tester strain(More)
The National Cancer Institute has contracted with Syracuse Research Corporation to produce monographs on the potential hazards of human exposure to approximately 70 chemicals used in the workplace. The monographs include detailed exposure data for specific job categories, as well as summaries of chemical and physical data, animal and human toxicological(More)
The 4-fluoro analogue of 17 beta-estradiol was investigated for estrogenic action in rats by determination of uterine hyperemia and [3H]uridine incorporation and was found to be an active estrogen. Antitumor activity of this analogue was demonstrated against 7,12-dimethylbenz[a]anthracene (DMBA) induced rat mammary adenocarcinoma. Its 13C NMR spectrum was(More)
The direct mutagenic activity of 1,1,2,3- tetrachloropropene and 1,1,2,3,3- pentachloropropene in Salmonella typhimurium was measured before and after incubation in the presence of intact segments of rat small intestine in vitro. The number of revertants in tester strain TA100 was reduced by about 95% when these chloropropenes were exposed to rat small(More)
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