Joseph R Lutt

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OBJECTIVES To familiarize rheumatologists and internists with the signs, symptoms, and management of orbital inflammatory disease (OID). METHODS A comprehensive literature review related to OID was performed and reported from the perspectives of rheumatology, ophthalmology, and radiology. RESULTS OID is a general term encompassing inflammatory diseases(More)
The introduction of medications that target specific proinflammatory cytokines has revolutionized the management of patients with rheumatoid arthritis. The agents that antagonize the effects of tumour necrosis factor (TNF)-alpha -- infliximab, etanercept and adalimumab -- have consistently shown very good efficacy for controlling the clinical and(More)
PURPOSE To determine associations between polymorphic genes that encode KIRs and their HLA class I ligands in patients with HLA-B27-associated acute anterior uveitis (AAU), with and without axial spondyloarthropathy (axial SpA). METHODS Molecular DNA typing methods were used to define the frequencies of variable KIR genes and their relevant HLA class I(More)
AIM Acute anterior uveitis (AAU) associated with HLA-B27 or axial spondyloarthritis (axial SpA) is primarily unilateral and recurrent. We tested the hypotheses that disease laterality and gender affected recurrences of AAU. METHODS We studied 207 AAU subjects who were either HLA-B27 positive or had a verified history of axial SpA with documentation of the(More)
Correspondence: Joseph R Lutt Division of Arthritis and Rheumatic Diseases, Oregon Health and Science University, Portland, Oregon, USA email luttj@ohsu.edu Abstract: The management of rheumatoid arthritis (RA) has undergone an impressive transformation over the past few decades. Further understanding of the pathophysiology of the disease process has(More)
The management of rheumatoid arthritis (RA) has undergone an impressive transformation over the past few decades. Further understanding of the pathophysiology of the disease process has resulted in the development of biologic agents that target proinflammatory cytokines and both B and T lymphocytes. By blocking an important costimulatory pathway, abatacept(More)
1. McDevitt HO, Sela M. Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med 1965;122:517–31. 2. Mozes E, McDevitt HO, Jaton JC, Sela M. The genetic control of antibody specificity. J Exp Med 1969;130:1263–78. 3. Van der Helm-van(More)
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