Joseph R. Leventhal

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To determine the prevalence of depression in Parkinson disease (PD) we evaluated 55 consecutive patients without dementia and 31 of their spouses. All subjects completed the Beck depression inventory and a quantitative mini-mental state examination. Using the Beck criteria, 47% of the patients and 12% of the spouses rated themselves as significantly(More)
The toxicity of chronic immunosuppressive agents required for organ transplant maintenance has prompted investigators to pursue approaches to induce immune tolerance. We developed an approach using a bioengineered mobilized cellular product enriched for hematopoietic stem cells (HSCs) and tolerogenic graft facilitating cells (FCs) combined with(More)
BACKGROUND Laparoscopic live donor nephrectomy (LDN) is a less invasive alternative to traditional open nephrectomy that has several potential advantages. However, there have been few large series reports describing the complications of LDN and the details of their management. METHODS We performed a retrospective review of 500 LDNs performed at our center(More)
n engl j med 366;17 nejm.org april 26, 2012 1648 The clinicians found that the patient’s international normalized ratio was essentially normal with a range of 1.1 to 1.2, but the prothrombin time was slightly prolonged (range, 13.1 to 14.2 seconds [reference range, 11.0 to 13.3]). Her severe thrombocytopenia, slightly prolonged prothrombin time, and normal(More)
BACKGROUND AND OBJECTIVES The optimal maintenance immunosuppressive regimen to improve long-term renal allograft function and graft survival is yet to be determined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This observational study prospectively compared tacrolimus/sirolimus with tacrolimus/mycophenolate mofetil in renal transplant recipients using a(More)
OBJECTIVES To analyzed our institution's 8-year experience (October 1997 through March 2006) with laparoscopic donor nephrectomy (LDN) and hand-assisted LDN (HALDN), comparing donor and recipient outcomes. METHODS A total of 482 LDNs were compared with 318 HALDNs with respect to donor sex, age, body mass index, hospital length of stay, donor and recipient(More)
BACKGROUND The current study examines the use of mycophenolate mofetil (MMF) and tacrolimus as primary immunosuppression in simultaneous pancreas-kidney (SPK) transplantation. In addition, analyses of the rates of conversion from one immunosuppressive agent to another, and its subsequent consequences with respect to outcomes were determined. Quality of(More)
The presence of donor-specific HLA antibodies before or after transplantation may have different implications based on the antibody strength. Yet, current approaches do not provide information regarding the true antibody strength as defined by antigen-antibody dissociation rate. To assess currently available methods, we compared between neat mean(More)
OBJECTIVES A standardized classification for the potential complications of living donor nephrectomy is an essential step in establishing a construct for monitoring and reporting the outcomes of this procedure. It is also helpful in informing potential donors about the inherent risks of the donor operation as part of the informed choice process. METHODS(More)
BACKGROUND Natural CD4CD25 regulatory T (Treg) cells have been implicated in suppressing alloreactivity in vitro and in vivo. We hypothesized that immunotherapy using ex vivo-expanded natural Treg could prevent acute allograft rejection in mice. METHODS Natural CD4+ CD25+ Treg were freshly purified from naive mice via automated magnetic cell sorter and(More)