Joseph Palackal Mathew

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BACKGROUND Studies that have shown clinical depression to be a risk factor for cardiac events after coronary artery bypass graft (CABG) surgery have had small sample sizes, short follow-up, and have not had adequate power to assess mortality. We sought to assess whether depression is associated with an increased risk of mortality. METHODS We assessed 817(More)
Since the introduction of transesophageal echocar-diography (TEE) to the operating room in the early 1980s, 1-4 its effectiveness as a clinical monitor to assist in the hemodynamic management of patients during general anesthesia and its reliability to make intraoperative diagnoses during cardiac operations has been well established. 5-26 In recognition of(More)
OBJECTIVE Although coronary artery bypass grafting (CABG) has been shown to improve quality of life and functional capacity for many patients, recent studies have demonstrated that a significant number of patients exhibit impairment in cognitive function immediately following surgery and beyond. We sought to determine the impact of this postoperative(More)
Millions of individuals with coronary artery or valvular heart disease have been given a new chance at life by heart surgery, but the potential for neurological injury is an Achilles heel. Technological advancements and innovations in surgical and anaesthetic technique have allowed us to offer surgical treatment to patients at the extremes of age and(More)
OBJECTIVE To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. MATERIALS AND METHODS Two hundred eighty patients (96 women and 184 men) underwent neurocognitive and QOL evaluation at baseline (preoperatively) and at 1 year(More)
The introduction of transesophageal echocardiogra-phy (TEE) in the mid-1980s extended the use of ultrasound to the intraoperative diagnosis and monitoring of cardiac and great vessel pathology. Intraop-erative epicardial echocardiography has been used both as an adjunct to TEE, and as a primary diagnostic tool in patients with contraindications to TEE. The(More)
During the last few decades, the utility of intraop-erative echocardiography has become increasingly evident as anesthesiologists, cardiologists, and surgeons continue to appreciate its potential application as an invaluable tool for monitoring cardiac performance and diagnosing pathology in patients undergoing cardiac surgery. 1,2 The essential information(More)
OBJECTIVE To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery. METHODS A total of 427 coronary artery bypass graft (CABG) patients were genotyped for two polymorphisms and(More)
for reviewing the manuscript in its early stages. EDITORIAL Editorials represent the opinions of the authors and JAMA and not those of the American Medical Association. A TRIAL FIBRILLATION IS BY FAR THE MOST COMMON complication following cardiac surgery, with an incidence consistently reported to range between 27% and 40% and with little change over the(More)
Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly. Understanding the role of pain signaling after surgery may lead to novel interventions for common complications such as delirium and postoperative cognitive dysfunction. Using a model of tibial fracture with intramedullary pinning in male(More)