The brown ghost knifefish (Apteronotus leptorhynchus) is a weakly electric teleost fish of particular interest as a versatile model system for a variety of research areas in neuroscience and biology. The comprehensive information available on the neurophysiology and neuroanatomy of this organism has enabled significant advances in such areas as the study of… (More)
Neuropeptides are a diverse category of signaling molecules in the nervous system regulating a variety of processes including food intake, social behavior, circadian rhythms, learning, and memory. Both the identification and functional characterization of specific neuropeptides are ongoing fields of research. Matrix-assisted laser desorption/ionization-time… (More)
Table 1: Selected compounds eHiTS scores from 8 of the 10 ERα structures evaluated.
Hydrogen/deuterium exchange (HDX) coupled to mass spectrometry permits analysis of structure, dynamics, and molecular interactions of proteins. HDX mass spectrometry is confounded by deuterium exchange-associated peaks overlapping with peaks of heavy, natural abundance isotopes, such as carbon-13. Recent studies demonstrated that high-performance mass… (More)
Virtual drug screening is a rapidly evolving technique which offers great promise for the systematic evaluation of large chemical libraries to identify potential drug candidates. eHiTS Lightning is a commercial drug design software which takes advantage of the Cell Broadband Engine processor present in the video game console Sony PlayStation 3 to greatly… (More)