Joseph Ojukwu

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BACKGROUND Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens. Several studies have investigated the relationship between genetic polymorphisms of CYP1B1 and breast cancer risk with inconsistent results. A G --> C transversion polymorphism in the heme-binding region in codon 432 of the(More)
The recent upsurge in global obesity and the recognition of the role of metabolic syndrome and other correlates of obesity in the etiology of breast cancer and other chronic diseases has created the impetus for renewed interest in the role of anthropometric measures in breast cancer risk. This case-control study was designed to evaluate the role of(More)
An account is given of 5 anal and 36 colorectal cancers occurring in Nigerians of the Igbo ethnic group. The rectum was the site of predilection for colorectal growths, and most rectal growths occurred in males. In contrast to the situation in the Western world the disease is rare, affects relatively younger patients, and is often advanced at presentation.(More)
This study was carried out in Benin City urban community, Nigeria as a follow-up of an earlier study carried out on patients admitted to the University of Benin Teaching Hospital. The aim of the present study was to determine the prevalence of asymptomatic rotavirus infection amongst urban children and adults. Eight hundred and twenty one subjects from 200(More)
BACKGROUND Breast cancer is the most common cancer and the leading cause of cancer related deaths in women worldwide. The incidence of the disease is increasing globally and this increase is occurring at a faster rate in population groups that hirtherto enjoyed low incidence. This study was designed to evaluate the role of a simple tandem repeat(More)
A rare disease that can mimic acute appendicitis is infarction of accessory spleen. It may occur in children and is difficult to diagnose preoperatively. Greater awareness of this entity may show not only that it is associated with other intraabdominal anomalies but also that it is more common in the tropics than elsewhere. Two cases are reported.
The incidence and determinants of post-operative wound infections in the University of Nigeria Teaching Hospital, Enugu was studied. During the period of study (July 1983-June 1984) 218 surgical operations from adult males and females were investigated. The overall infection rate was found to be 27.98 percent. The incidence rate in clean wounds was 14(More)
Three cases of unusual craniocerebral injuries caused by deliberate driving of nails into the head are reported. All injuries were on or near the midline in the parietal area and the nails measured about 10 cm. Two of the patients experienced little pain during the procedure and did not lose consciousness. The extraction of each nail was extremely easy. The(More)