Joseph Mendelis

Learn More
BACKGROUND Cardiovascular progenitor cells (CPCs) have been identified within the developing mouse heart and differentiating pluripotent stem cells by intracellular transcription factors Nkx2.5 and Islet 1 (Isl1). Study of endogenous and induced pluripotent stem cell (iPSC)-derived CPCs has been limited due to the lack of specific cell surface markers to(More)
STUDY DESIGN Laboratory study. OBJECTIVE To evaluate whether blockade of the Substance P (SP) NK1R attenuates its proinflammatory effect on human intervertebral disc cells (IVD), and to evaluate the signaling pathways associated with SP. SUMMARY OF BACKGROUND DATA SP and its receptors are expressed in human IVD cells, and cause upregulation of(More)
STUDY DESIGN Laboratory study. OBJECTIVE To evaluate the differential gene expression of cytokines and growth factors in anterior versus posterior annulus fibrosus (AF) intervertebral disc (IVD) specimens. SUMMARY OF BACKGROUND DATA Histological analysis has demonstrated regional differences in vascular and neural ingrowth in the IVD, and similar(More)
  • 1