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Mitochondria accumulate at neuronal and immunological synapses and yeast bud tips and associate with the ER during phospholipid biosynthesis, calcium homeostasis, and mitochondrial fission. Here we… (More)
Proteases play essential roles in protein degradation, protein processing, and extracellular matrix remodeling in all cell types and tissues. They are also involved in protein turnover for… (More)
Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be… (More)
Upon synaptic vesicle fusion, the neuronal membrane surface expands. Clathrin-mediated endocytosis compensates for this expansion but is a slow process. Recent studies in eLife and Nature identify an… (More)
Thyroid hormone (TH) target cells need to adopt mechanisms to maintain sufficient levels of TH to ensure regular functions. This includes thyroid epithelial cells, which generate TH in addition to… (More)
1VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; 2Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium; 3Baylor College of Medicine, Jan and Dan… (More)