Joseph M Martin

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BACKGROUND Cow's milk has been implicated as a possible trigger of the autoimmune response that destroys pancreatic beta cells in genetically susceptible hosts, thus causing diabetes mellitus. Studies in animals have suggested that bovine serum albumin (BSA) is the milk protein responsible, and an albumin peptide containing 17 amino acids (ABBOS) may be the(More)
Novel molecular tools and genetic methods were developed to isolate genomic fragments of Mycobacterium tuberculosis that may be associated with virulence. We sought to restore virulence, a characteristic of M. tuberculosis that is correlated with growth rate in mouse spleen and lung tissue, to the avirulent strain H37Ra by complementation. A representative(More)
The etiology of insulin-dependent diabetes mellitus (IDDM) is multifactorial. The final cause of the disease, the specific destruction of the islet beta-cells, is the result of a cellular/humoral autoimmune process that operates in individuals with a particular genetic background in response to an external triggering factor(s). The most likely environmental(More)
BACKGROUND AND PURPOSE The direct and indirect costs associated with head injuries from stroke or trauma approach $200 billion a year in the United States alone. 1,2 At the completion of standard of care motor retraining (6 to 9 months post stroke), individuals present with varying levels of upper-extremity (UE) functional recovery. Their recovery depends(More)
Animals from a colony of spontaneously diabetic insulin-dependent BB rats were fed from weaning with semisynthetic diets in which natural proteins were replaced by l-amino acids with or without the addition of either milk or wheat proteins. The normal 50% incidence of diabetes in the colony was reduced to 15% in rats fed the basic semi-synthetic diet, while(More)
Environmental "triggers" (including viruses, toxins and dietary factors) have been implicated in the pathogenesis of insulin-dependent diabetes mellitus. Data have suggested a possible role for cow's milk protein (CMP) as a trigger of diabetes. To study this further, 86 BB rats were divided into 2 groups during the weaning period (days 13-25): Group A(More)
Insertional mutagenesis in Mycobacterium bovis BCG, a member of the slow-growing M. tuberculosis complex, was accomplished with transposons engineered from the Mycobacterium smegmatis insertion element IS1096. Transposons were created by placing a kanamycin resistance gene in several different positions in IS1096, and the resulting transposons were(More)
Western blotting of either a cloned rat beta-islet tumour cell extract or isolated BB rat islets with rat anti-bovine serum albumin antiserum revealed a cross-reacting protein (Mr = 69,000). A protein of similar molecular size was observed by fluorography in proteins immunoprecipitated from islet cells labelled with (35S)-methionine using anti-bovine serum(More)