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Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening.
Identification of chemicals that pose a hazard to the developing nervous system is the first step in reducing human exposure and preventing health risks to infants and children. In response to theExpand
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Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science.
In vitro, high-throughput methods have been widely recommended as an approach to screen chemicals for the potential to cause developmental neurotoxicity and prioritize them for additional testing.Expand
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L-Tyrosine Contributes to (+)-3,4-Methylenedioxymethamphetamine-Induced Serotonin Depletions
The specific mechanisms underlying (+)-3,4-methylenedioxymethamphetamine (MDMA)-induced damage to 5-HT terminals are unknown. Despite the hypothesized role for dopamine (DA) and DA-derived freeExpand
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Expanding the test set: Chemicals with potential to disrupt mammalian brain development.
High-throughput test methods including molecular, cellular, and alternative species-based assays that examine critical events of normal brain development are being developed for detection ofExpand
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Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells.
There is considerable public concern that the majority of commercial chemicals have not been evaluated for their potential to cause developmental neurotoxicity. Although several chemicals areExpand
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Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications.
Toxicogenomics is the application of toxicology, genetics, molecular biology and environmental health to describe the response of organisms to environmental stimuli. The field of toxicogenomics hasExpand
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