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Reconstructing full-length transcript isoforms from sequence fragments (such as ESTs) is a major interest and challenge for bioinformatic analysis of pre-mRNA alternative splicing. This problem has been formulated as finding traversals across the splice graph, which is a directed acyclic graph (DAG) representation of gene structure and alternative splicing.(More)
Two types of chemotherapy used in the treatment of patients with malignant glioma are carboplatin and Gliadel wafer [(3.85% 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU)]. To date there have been no published data examining their concurrent use in this disease. The purpose of this study was to evaluate combination chemotherapy with Gliadel wafer and(More)
BACKGROUND Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA(More)
The HIV positive selection mutation database is a large-scale database available at http://www.bioinformatics.ucla.edu/HIV/ that provides detailed selection pressure maps of HIV protease and reverse transcriptase, both of which are molecular targets of antiretroviral therapy. This database makes available for the first time a very large HIV sequence dataset(More)
  • Joseph W Kim, A R M Ruhul Amin, Dong M Shin
  • 2010
Recently, squamous cell carcinoma of the head and neck chemoprevention research has made major advances with novel clinical trial designs suited for the purpose, use of biomarkers to identify high-risk patients, and the emergence of numerous molecularly targeted agents and natural dietary compounds. Among many natural compounds, green tea polyphenols,(More)
Ubiquitous computing technology enables new forms of creative expression, but the exploration of ubicomp in the arts and entertainment communities requires unique design considerations. Specifically, this paper suggests that the myth of interface independence and the assumption that authoring comes for free are particularly problematic for artistic(More)
—Occasionally, participants in a meeting can leave with different understandings of what had been discussed. For meetings that require immediate response (such as disaster response planning), the participants must share a common understanding of the decisions reached by the group to ensure successful execution of their mission. In such domains,(More)