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Social approach is crucial for establishing relationships among individuals. In rodents, social approach has been studied primarily within the context of behavioral phenomena related to sexual reproduction, such as mating, territory defense and parental care. However, many forms of social interaction occur before the onset of reproductive maturity, which(More)
a r t i c l e i n f o a b s t r a c t Creativity is likely to be related to intelligence, though the nature of this relationship remains largely unresolved and few studies have examined creativity in the context of measures traditionally related to intelligence. Like intelligence, creativity has often been studied as a static trait or as subject to change(More)
Reconstructing full-length transcript isoforms from sequence fragments (such as ESTs) is a major interest and challenge for bioinformatic analysis of pre-mRNA alternative splicing. This problem has been formulated as finding traversals across the splice graph, which is a directed acyclic graph (DAG) representation of gene structure and alternative splicing.(More)
BACKGROUND Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA(More)
OBJECTIVE To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life. DESIGN Randomised placebo controlled double blind trial. SETTING General practices in United Kingdom (384), Australia (94), and New Zealand (24). PARTICIPANTS Postmenopausal women aged 50-69 at randomisation; 3721 women with a uterus were(More)
The HIV positive selection mutation database is a large-scale database available at http://www.bioinformatics.ucla.edu/HIV/ that provides detailed selection pressure maps of HIV protease and reverse transcriptase, both of which are molecular targets of antiretroviral therapy. This database makes available for the first time a very large HIV sequence dataset(More)
Ubiquitous computing technology enables new forms of creative expression, but the exploration of ubicomp in the arts and entertainment communities requires unique design considerations. Specifically, this paper suggests that the myth of interface independence and the assumption that authoring comes for free are particularly problematic for artistic(More)