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The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus) has been determined at 2.5 A resolution, providing a description of how FK506 functions at the atomic level. In the structure, the FKBP12-FK506 binary complex does not contact the phosphatase active(More)
Human cancer genomes harbour a variety of alterations leading to the deregulation of key pathways in tumour cells. The genomic characterization of tumours has uncovered numerous genes recurrently mutated, deleted or amplified, but gene fusions have not been characterized as extensively. Here we develop heuristics for reliably detecting gene fusion events in(More)
BACKGROUND Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA(More)
In this first part of a two-part study, experiments were performed to investigate condensation of FC-72 along parallel, square micro-channels with a hydraulic diameter of 1 mm and a length of 29.9 cm, which were formed in the top surface of a solid copper plate. The condensation was achieved by rejecting heat to a counter flow of water through channels(More)
—Occasionally, participants in a meeting can leave with different understandings of what had been discussed. For meetings that require immediate response (such as disaster response planning), the participants must share a common understanding of the decisions reached by the group to ensure successful execution of their mission. In such domains,(More)
—We describe the design of an aerial robot inspired by birds and the underlying theoretical developments leading to novel control and closed-loop guidance algorithms for a perching maneuver. A unique feature of this robot is that it uses wing articulation to control the flight path angle as well as the heading angle. It lacks a vertical tail for improved(More)
BACKGROUND Gastric cancer samples obtained by histologic macrodissection contain a relatively high stromal content that may significantly influence gene expression profiles. Differences between the gene expression signature derived from macrodissected gastric cancer samples and the signature obtained from isolated gastric cancer epithelial cells from the(More)
Peptide nucleic acids have emerged over the past two decades as a promising class of nucleic acid mimics because of their strong binding affinity and sequence selectivity toward DNA and RNA, and resistance to enzymatic degradation by proteases and nucleases. While they have been shown to be effective in regulation of gene expression in vitro, and to a small(More)