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BACKGROUND A number of US observational studies reported an increased mortality risk with higher intact parathyroid hormone (iPTH), calcium and/or phosphate. The existence of such a link in a European haemodialysis population was explored as part of the Analysing Data, Recognising Excellence and Optimising Outcomes (ARO) Chronic Kidney Disease (CKD)(More)
Mutations of the RET proto-oncogene are responsible for several inherited human diseases and may function as genetic modifiers of the disease. However, the role of RET mutations in pancreatic cancer has not been studied. Expression of the glial cell line-derived neurotrophic factor (GDNF) receptors RET and GDNF family receptor alpha1 (GFRalpha1) in human(More)
Reconstructing full-length transcript isoforms from sequence fragments (such as ESTs) is a major interest and challenge for bioinformatic analysis of pre-mRNA alternative splicing. This problem has been formulated as finding traversals across the splice graph, which is a directed acyclic graph (DAG) representation of gene structure and alternative splicing.(More)
By " listening in " to ongoing dialogues between customers and Web-based virtual advisers (e.g., Kelley Blue Book's Auto Choice Advisor), the authors identify new product opportunities based on new combinations of customer needs. The data are available at little incremental cost and provide the scale necessary for complex products (e.g., 148 trucks and 129(More)
BACKGROUND Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA(More)
The HIV positive selection mutation database is a large-scale database available at http://www.bioinformatics.ucla.edu/HIV/ that provides detailed selection pressure maps of HIV protease and reverse transcriptase, both of which are molecular targets of antiretroviral therapy. This database makes available for the first time a very large HIV sequence dataset(More)
In this first part of a two-part study, experiments were performed to investigate condensation of FC-72 along parallel, square micro-channels with a hydraulic diameter of 1 mm and a length of 29.9 cm, which were formed in the top surface of a solid copper plate. The condensation was achieved by rejecting heat to a counter flow of water through channels(More)
Previously assumed to be a select ligand for chemokine receptor CXCR4, chemokine CXCL12 is now known to activate both CXCR4 and CXCR7. However, very little is known about the co-expression of these receptors in cancer cells. We used immunohistochemistry to determine the extent of co-expression in pancreatic cancer tissue samples and immunoblotting to verify(More)
OBJECTIVE To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life. DESIGN Randomised placebo controlled double blind trial. SETTING General practices in United Kingdom (384), Australia (94), and New Zealand (24). PARTICIPANTS Postmenopausal women aged 50-69 at randomisation; 3721 women with a uterus were(More)
—We describe the design of an aerial robot inspired by birds and the underlying theoretical developments leading to novel control and closed-loop guidance algorithms for a perching maneuver. A unique feature of this robot is that it uses wing articulation to control the flight path angle as well as the heading angle. It lacks a vertical tail for improved(More)