Francis K. L. Chan9
Martin C. S. Wong4
Jessica Y. L. Ching4
Thomas Y. T. Lam4
9Francis K. L. Chan
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Host immune peptides, including cathelicidins, have been reported to possess anticancer properties. We previously reported that LL-37, the only cathelicidin in humans, suppresses the development of colon cancer. In this study, the potential anticancer effect of FK-16, a fragment of LL-37 corresponding to residues 17 to 32, on cultured colon cancer cells was(More)
BACKGROUND Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common in multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is one of the downregulated genes we identified through(More)
  • Martin C. S. Wong, Jessica Y. L. Ching, Hoyee H. Hirai, Thomas Y. T. Lam, Sian M. Griffiths, Francis K. L. Chan +1 other
  • 2013
PURPOSE to evaluate the proportion of self-referred screening participants having various psychological barriers and the factors associated with these barriers. METHODS A territory-wide bowel cancer screening centre sent an invitation via the media to all Hong Kong residents aged 50-70 years who were asymptomatic of CRC to join a free screening programme.(More)
  • Chung-Wah Wu, Yu-Juan Dong, Qiao-Yi Liang, Xin-Qi He, Simon S. M. Ng, Francis K. L. Chan +2 others
  • 2013
BACKGROUND miR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling. In this study, we examined the functional significance of miR-18a in CRC. METHODS Expression of miR-18a was investigated in 45 CRC patients. Potential target genes of miR-18a were predicted by in silico search and confirmed by luciferase(More)
Hydrogen sulfide (H(2)S) is a gaseous bacterial metabolite that reaches high levels in the large intestine. In the present study, the effect of H(2)S on the proliferation of normal and cancerous colon epithelial cells was investigated. An immortalized colon epithelial cell line (YAMC) and a panel of colon cancer cell lines (HT-29, SW1116, HCT116) were(More)
Whether severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection can be asymptomatic is unclear. We examined the seroprevalence of SARS-CoV among 674 healthcare workers from a hospital in which a SARS outbreak had occurred. A total of 353 (52%) experienced mild self-limiting illnesses, and 321 (48%) were asymptomatic throughout the(More)
  • Martin C. S. Wong, Hoyee W. Hirai, Arthur K. C. Luk, Thomas Y. T. Lam, Jessica Y. L. Ching, Sian M. Griffiths +2 others
  • 2013
OBJECTIVES We tested the a priori hypothesis that self-perceived and real presences of risks for colorectal cancer (CRC) are associated with better knowledge of the symptoms and risk factors for CRC, respectively. METHODS One territory-wide invitation for free CRC screening between 2008 to 2012 recruited asymptomatic screening participants aged 50-70(More)
Colorectal cancer (CRC) is one of the leading causes of cancer mortality worldwide. This study examined factors influencing the choice of participants between colonoscopy and fecal immunochemical test (FIT) in a screening program and the impact of an unbiased educational session on influencing this decision. Data from 7,845 participants who underwent(More)
BACKGROUND PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in multiple cellular regulations by acting as epigenetic modifiers. We studied a recently identified PRDM member PRDM5 for its epigenetic abnormality and tumor suppressive functions in multiple tumorigeneses. METHODOLOGY/PRINCIPAL FINDINGS Semi-quantitative(More)
Extraction of meaningful information from large experimental data sets is a key element in bioinformatics research. One of the challenges is to identify genomic markers in Hepatitis B Virus (HBV) that are associated with HCC (liver cancer) development by comparing the complete genomic sequences of HBV among patients with HCC and those without HCC. In this(More)