Joseph J. López

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Adrenergic stimulation modulates cardiac function by altering the phosphorylation status of several cardiac proteins. The Troponin complex, which is the Ca(2+) sensor for cardiac contraction, is a hot spot for adrenergic phosphorylation. While the effect of β-adrenergic related PKA phosphorylation of troponin I at Ser23/24 is well established, the effects(More)
Parvalbumin (PV), an EF-hand protein family member, is a delayed calcium buffer that exchanges magnesium for calcium to facilitate fast skeletal muscle relaxation. Genetic approaches that express parvalbumin in the heart also enhance relaxation and show promise of being therapeutic against various cardiac diseases where relaxation is compromised.(More)
INTRODUCTION: Regenerative Peripheral Nerve Interfaces (RPNIs) are promising for interfacing human intentions to myoelectric prostheses. Rat studies led to proof of internal RPNI long-term function and high signal to noise ratio with no adverse biological effects.
Hyperthermia therapy has recently emerged as a clinical modality used to finely tune heat stress inside the human body for various biomedical applications. Nevertheless, little is known regarding the optimal timing or temperature of heat stress that is needed to achieve favorable results following hyperthermia therapy for muscle regeneration purposes. The(More)
This study investigates the efficacy of local and intravenous mesenchymal stem cell (MSC) administration to augment neuroregeneration in both a sciatic nerve cut-and-repair and rat hindlimb transplant model. Bone marrow-derived MSCs were harvested and purified from Brown-Norway (BN) rats. Sciatic nerve transections and repairs were performed in three groups(More)
CONCLUSION: Both double innervation techniques (ES and CEE) showed earlier and greater functional recovery of the gastrocnemius muscle when compared with simple inner-vation technique (EE). Animals of the CEE group showed higher number of regenerated axons in the distal stump of the repaired nerve than animals of the others experimental groups.(More)
Lessons learned from lethal cardiac injury by nuss repair of pectus excavatum in a 16-year-old. Cardiac perforation by a pec-tus bar after surgical correction of pectus excavatum: case report and review of the literature. INTRODUCTION: Hyperthermia therapy has recently emerged as a clinical modality used to finely tune heat stress inside the human body for(More)
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