Joseph J. Capowski

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BACKGROUND In retinopathy of prematurity (ROP), tortuosity of vessels near the posterior pole of the fundus is an important clinical sign, yet clinicians have difficulty estimating how tortuous the vessels are. METHODS The authors have devised an objective, numeric index of retinal blood vessel tortuosity that is especially sensitive to the structural(More)
Computer graphics displays in the neurosciences are classified into three categories: anatomical structures, physiological waveforms, and statistical summaries. The capabilities required in a line drawing system to present neuroscience displays are smooth rotation and translation of 3D structures, simple line rejection, orthographic projection, and flexible(More)
BACKGROUND Abnormally increased diameter and tortuosity of retinal blood vessels in the posterior pole, or "plus disease," is recognized as a powerful predictor of poor outcome in eyes with retinopathy of prematurity (ROP). Although the diagnosis of plus disease depends upon the examiner's ability to examine retinal blood vessels, the ability of the human(More)
Most contemporary neuron tracing systems are semi-automatic; that is, an operator follows neuron branches in a microscope or on a data tablet and instructs a computer when to record a spatial sample. A list of such samples is then used to generate a display of the neuron and to summarize statistically its structure. The tracing is tedious, and the operator(More)
Semiautomatic systems designed to trace neurons in three dimensions are slow and require many hours of work on the part of a human operator to trace even a single neuron completely. Attempts at constructing fully automatic systems have met with only limited success because of the dual problems of slow speed of travel down a fiber and time/space limitations(More)
A system of programs for building three-dimensional models of biological structures was developed. Outlines of features such as cells, tissue edges, and neuron pathways are traced into a computer from tissue sections mounted on a light microscope or projected onto a data tablet. The three-dimensional models are built from a series of the two-dimensional(More)
The spinal cords of adult cats were impregnated using the Golgi-Kopsch technique and cut in the sagittal plane. Richly arborizing axon-trees were found in the substantia gelatinosa (lamina II of Rexed). Axon arborizations, characterized by a long rostro-caudal course, a single-stem fiber, multiple-arborizing side branches and large terminal and en passant(More)