Joseph Goodman

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The mechanism(s) by which Mycobacterium tuberculosis crosses the alveolar wall to establish infection in the lung is not well known. In an attempt to better understand the mechanism of translocation and create a model to study the different stages of bacterial crossing through the alveolar wall, we established a two-layer transwell system. M. tuberculosis(More)
To determine whether serum albumin levels, before first surgery, predict time until death, 24 glioblastoma multiforme patients newly diagnosed at Ohio State University and Cleveland Clinic Foundation Hospitals between 1993 and 1995 were followed until 1996. Patients with presurgical serum albumin levels below 3.4 mg/dL survived an average (median) of 62(More)
9alpha-Fluorohydrocortisone is hydroxylated by Streptomyces roseochromogenes in the 16alpha-, the 2beta-, and in both the 16alpha- and 2beta- positions. 16alpha-Hydroxylation appears to be the more predominant and rapid pathway of transformation. The degree of 2beta-hydroxylation is dependent upon the strain used and may be increased to the point of its(More)
Treatment of fragmented preparations of sarcoplasmic reticulum with diethyl ether decreases the calcium uptake capacity of reticulum, while the ATP-binding capacity as well as the ATP-splitting activity of reticulum were increased. Diethyl ether-treated reticulum preparations retained both the “basal” and the “extra” splitting activities of Hasselbach and(More)
The producing organism for the new broad spectrum glycocinnamoylspermidine antibiotics designated LL-BM123beta, gamma1 and gamma2 was characterized as a Nocardia sp. by chemical analysis of the cell wall, growth requirements, morphology and physiological reactions. Fermentation conditions to elaborate and analytical methods to characterize these antibiotics(More)
The biosynthesis of LL-F28249 alpha in a culture of Streptomyces cyaneogriseus has been studied using 13C, 14C and 18O labeled precursors. A complete 13C NMR spectrum of F28249 alpha has been assigned. Incorporation studies using 13C labeled precursors indicate that the carbon skeleton of F28249 alpha is derived from seven acetate, six propionate and one(More)
Antibacterial antibiotics LL-E19020 alpha and beta were isolated from the fermentation broth of an actinomycete strain. Based on cultural and physiological characteristics, culture LL-E19020 was identified as a new subspecies of Streptomyces lydicus. The LL-E19020 alpha and beta antibiotics were found to possess a very narrow antibacterial spectrum against(More)
Bromide and thiocyanate have been shown to be effective inhibitors of the chlorination process leading to chlortetracycline formation by certain strains of Streptomyces aureofaciens Duggar (Gourevitch et al., 1955; Doerschuk, et at., 1956). Sekizawa (1955) reported thiourea, 2-thiouracil, 2-mercaptobenzothiazole, and thioglycolic-f3-aminonaphthalide(More)