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Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: molecular and behavioral aspects.

• Itzhak Levi, Yael Eskira, +8 authors Orna Almog
• European neuropsychopharmacology : the journal of…
• 2013

Bipolar-disorder (manic-depressive illness) is a severe chronic illness affecting ∼1% of the adult population. It is treated with mood-stabilizers, the prototypic one being lithium-salts (lithium),… (More)

Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3.

• Michael Weinmüller, Florian Rechenmacher, +13 authors Horst Kessler
• Angewandte Chemie
• 2017

A highly systematic approach for the development of both orally bioavailable and bioactive cyclic N-methylated hexapeptides as high affinity ligands for the integrin αvβ3 is based on two concepts: a)… (More)

The Calbindin-D 28 k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action

• Orna Almog, Itzhak Levi, +6 authors Galila Agam
• 2011

Orna Almog, Itzhak Levi 1,2,3 ,Yael Eskira, Miriam Eisenstein, Chaim Gilon, Amnon Hoffman, Yiftach Talgan, Joseph Fanous, and Galila Agam Department of Clinical Biochemistry, Faculty of Health… (More)

Superiority of the S,S conformation in diverse pharmacological processes: Intestinal transport and entry inhibition activity of novel anti-HIV drug lead.

• Joseph Fanous, Avi Swed, +5 authors Amnon Hoffman
• International journal of pharmaceutics
• 2015

Chirality is an important aspect in many pharmacological processes including drug transport and metabolism. The current investigation examined the stereospecific transport and entry inhibitory… (More)

The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons.

• Pavel Gershkovich, Joseph Fanous, Bashir Qadri, Avihai Yacovan, Shimon Amselem, Amnon Hoffman
• The Journal of pharmacy and pharmacology
• 2009

OBJECTIVES The uptake of drugs by chylomicrons is a key element in both intestinal lymphatic transport and postprandial alterations in the disposition profile of lipophilic drugs. The aim of this… (More)

Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site.

• Markus Bollinger, Florian Manzenrieder, +11 authors Horst Kessler
• Journal of medicinal chemistry
• 2012

Intervention in integrin-mediated cell adhesion and integrin signaling pathways is an ongoing area of research in medicinal chemistry and drug development. One key element in integrin-ligand… (More)

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