Joseph F. Harrison

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OBJECTIVE To evaluate the pharmacokinetics and pharmacodynamics of recombinant activated factor VII (rFVIIa). METHODS Single-dose pharmacokinetics of three dose levels (17.5, 35, and 70 micrograms/kg) of rFVIIa were investigated in 15 patients with hemophilia with severe factor VIII or factor IX deficiency (with or without inhibitors) while they were in(More)
The safety and efficacy of recombinant DNA-produced factor VIIa (rFVIIa) was investigated in 15 haemophilic patients in non-bleeding states and during bleeding episodes (mild to moderate joint bleed). Patients with severe haemophilia A without inhibitors (n = 4), haemophilia A with inhibitors (n = 10), and haemophilia B with inhibitor (n = 1) received one(More)
Despite the large body of work in both motion planning and multi-agent simulation, little work has focused on the problem of planning motion for groups of robots using external “controller” agents. We call this problem the group control problem. This problem is complex because it is highly underactuated, dynamic, and requires multi-agent(More)
In this paper, we present a new motion planning strategy for shepherding in environments containing obstacles. This instance of the group motion control problem is applicable to a wide variety of real life scenarios, such as animal herding simulation, civil crowd control training, and oil-spill cleanup simulation. However, the problem is challenging in(More)
To determine the current incidence of hepatitis B core antibody (anti-HBc) in a healthy blood donor population, 1,893 donors were screened for anti-HBc. Forty-one (2.16%) were found to be initially positive and 35 (1.85%) repeatably positive. Sera from the repeatably positive donors were further screened for hepatitis B surface antibody (anti-HBs), and(More)
This paper describes a stylized model of internally displaced person (IDP) dynamics in East Africa. Displaced people often require support from national governments, international agencies or major non-governmental organizations. Anticipating the timing and magnitude of displacement events, as well as the likely locations to which displaced people will move(More)