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Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an SLE-like disease.(More)
A. Personal Statement Crowd wisdom may be a powerful force to transform sexual health campaigns. My research focuses on this and related sexual health research bringing together infectious diseases, innovation, and social science. I have sixteen years of experience undertaking HIV/STI research in low and middle income country contexts. Much of my research(More)
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