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A spatial and temporal map of C. elegans gene expression.
The C. elegans genome has been completely sequenced, and the developmental anatomy of this model organism is described at single-cell resolution. Here we utilize strategies that exploit thisExpand
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Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors
Polymodal nociceptors detect noxious stimuli, including harsh touch, toxic chemicals and extremes of heat and cold. The molecular mechanisms by which nociceptors are able to sense multipleExpand
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Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans.
Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe the structure andExpand
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Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system
BackgroundWith its fully sequenced genome and simple, well-defined nervous system, the nematode Caenorhabditis elegans offers a unique opportunity to correlate gene expression with neuronalExpand
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Netrin (UNC-6) mediates dendritic self-avoidance
Dendrites from a single neuron may be highly branched but typically do not overlap. Self-avoidance behavior has been shown to depend on cell-specific membrane proteins that trigger mutual repulsion.Expand
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The embryonic muscle transcriptome of Caenorhabditis elegans
BackgroundThe force generating mechanism of muscle is evolutionarily ancient; the fundamental structural and functional components of the sarcomere are common to motile animals throughout phylogeny.Expand
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Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration
Mitochondria are key regulators of cell viability and provide essential functions that protect against neurodegenerative disease. To develop a model for mitochondrial-dependent neurodegeneration inExpand
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A Transcriptional Program Promotes Remodeling of GABAergic Synapses in Caenorhabditis elegans
Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely undefined. In Caenorhabditis elegans, GABAergicExpand
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Optogenetic Analysis of a Nociceptor Neuron and Network Reveals Ion Channels Acting Downstream of Primary Sensors
BACKGROUND Nociception generally evokes rapid withdrawal behavior in order to protect the tissue from harmful insults. Most nociceptive neurons responding to mechanical insults display highlyExpand
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Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system
BackgroundDNA microarrays provide a powerful method for global analysis of gene expression. The application of this technology to specific cell types and tissues, however, is typically limited byExpand
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