Joseph Clarke

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Neurofibrillary tangles and amyloid plaques are considered to be hallmarks of Alzheimer's disease (AD), and the toxic effects of amyloid-beta peptide (A beta) lead to activation of stress-related signaling and neuronal loss. The small heat shock protein Hsp27 is reported to be increased in AD brains and to accumulate in plaques, but whether this represents(More)
Previous studies have suggested that the small heat shock protein, HspB1, has a direct influence on the dynamics of cytoskeletal elements, in particular, filamentous actin (F-actin) polymerization. In this study we have assessed the influence of HspB1 phosphorylation on its interaction(s) with F-actin. We first determined the distribution of endogenous(More)
Saving energy in residential and commercial buildings is of great interest due to diminishing resources. Heating ventilation and air conditioning systems, and electric lighting are responsible for a significant share of energy usage, which makes it desirable to optimise their operations while maintaining user comfort. Such optimisation requires accurate(More)
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