Imprecision is well suited for representing uncertainty in choice during an engineering design process, and in particular for computer aided engineering design and analysis tools. To propagate imprecise understanding through engineering tools, however, rst the membership functions must be constructed based on the understandings of the design engineer. To… (More)
Human pluripotent stem cells (hPSCs) constitute a promising resource for use in cell-based therapies and a valuable in vitro model for studying early human development and disease. Despite significant advancements in the derivation of specific fates from hPSCs, the generation of skeletal muscle remains challenging and is mostly dependent on transgene… (More)
This paper outlines a method for propagating imprecise constraints in engineering design. An interactive CAD tool implementation is described. To enable rapid propagation, we develop an extension of the Level Interval Algorithm capable of handling arbitrary nonlinear constraints, and implement it in the CAD tool. A simple engineering example is illustrated.
All Rights Reserved iii Acknowledgements First, I would like to thank my advisor, Rod Goodman, for providing me with the resources and tools necessary to produce this work. Next, I would like to thank the members of my thesis defense committee, Martin, and Chris Diorio. I would also like to thank Petr Vogel for being on my candidacy committee. Thanks also… (More)
In skeletal muscle cells, GLUT1 is responsible for a large portion of basal uptake of glucose and dehydroascorbic acid, both of which play roles in antioxidant defense. We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase… (More)
OBJECTIVE The glucose and dehydroascorbic acid (DHA) transporter GLUT1 contains a phosphorylation site, S490, for ataxia telangiectasia mutated (ATM). The objective of this study was to determine whether ATM and GLUT1-S490 regulate GLUT1. RESEARCH DESIGN AND METHODS L6 myoblasts and mouse skeletal muscles were used to study the effects of ATM inhibition,… (More)
1 We examine phrase alignment in a hybrid con-nectionist framework. We describe the architecture and the learning algorithm of our approach. Simulations have been carried out to demonstrate the feasibility of this approach using a real-world title phrase corpus. Although the results of our approach are still at an early stage, we found that a hybrid… (More)
1 We examine phrase alignment in a hybrid connectionist framework. We describe the architecture and the learning algorithm of our approach. Simulations have been carried out to demonstrate the feasibility of this approach using two corpora. Although the results of our approach are still at an early stage, we found that a hybrid approach to phrase alignment… (More)