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OBJECTIVE The factor structures of individual positive and negative symptoms as well as global ratings were examined in a diagnostically heterogeneous group of subjects. METHOD Subjects were identified through a clinical and family study of patients with major psychoses at a VA medical center and evaluated with the Scale for the Assessment of Negative(More)
Past literature suggests that schizophrenic men and women may be at different risks for developing different subtypes of schizophrenia. This hypothesis was tested using data from the well-known retrospective cohort family studies, the Iowa 500 and the Iowa non-500. The sample consisted of 171 male and 161 female DSM-III schizophrenic patients and 713 of(More)
Studies of the increased or decreased risk of specific physical diseases in patients with schizophrenia and affective disorder are reviewed. Existing data suggest further examination of the following relationships: (1) the presence in schizophrenics of increased incidence of gastrointestinal cancer and of cardiovascular and infectious diseases, and of(More)
Hospital records of 72 drug abusers with psychoses (DAP) were analyzed to clarify the relationship between drug abuse and psychosis. Comparison groups included schizophrenics and atypical schizophrenics without drug abuse and drug abusers without psychoses (DA). Compared with DAP in whom psychoses lasted less than six months before admission (DAP-short),(More)
Results from a 40-year followup study of psychotic patients are presented to illustrate some of the major findings and unanswered questions about excess mortality in schizophrenia and to suggest analytical approaches that take full account of the potential effects of sample heterogeneity. In this study, hospital-diagnosed schizophrenia patients were at(More)
We compared the factor structure of positive and negative symptoms in schizophrenia (N = 214), major depression (N = 97), and bipolar disorder (N = 58) to determine whether schizophrenia factors would generalize to mood disorders. A study of schizophrenia and mood disorders identified patients whose symptoms were evaluated with the Scale for the Assessment(More)
Psychiatry as a medical discipline has a special concern for preventing premature deaths in psychiatric patients. Such patients continue to be at excess mortality risk despite changing patterns of causes of death and improvements in the treatment of some diagnostic groups. In this overview of current findings and research trends, we find a continuing need(More)
A wide variety of concepts have been proposed to account for schizoaffective psychoses. Presenting a mixture of schizophrenic and affective symptoms, these psychoses have long defied classification in the usual scheme of the two major diagnostic categories, schizophrenia and major affective disorder. Empirical findings are often contradictory, and have(More)
Outcome studies of schizoaffective disorder have taught us much about the long-term consequences of the syndrome, and they have provided some indication of the potential usefulness of maintaining "schizoaffective disorder" as a diagnostic category separate from schizophrenia and major affective disorder. In a review of outcome studies that compared(More)
Female schizophrenics have been reported to have a better prognosis than male schizophrenics. However, earlier reports rarely used either operational criteria for schizophrenia or appropriate comparison groups. Using data collected as part of a long-term follow-up and family study, the authors examined outcome by sex of 186 schizophrenics, 212 depressives,(More)