Joseph Benoît

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A new compound, 8[[3-[4-(2-[(11)C]methoxyphenyl)piperazin-1-yl]-2-hydroxypropyl]oxy]thiochroman was labeled via O-methylation with [(11)C]methyl iodide in good yield and specific activity. Original biological evaluations included (i) the study in anesthetized rat with a beta-sensitive intracerebral probe (beta-Microprobe), allowing to measure locally the(More)
The passive transfer of rabbit anti-mycobacterial immunoglobulins was directed against either living or soluble extracts of Mycobacterium tuberculosis strain H37Rv, which promotes the multiplication of the BCG strain of M. tuberculosis in the spleen of mice infected with low doses of this latter strain. This enhancing effect was reduced significantly when(More)
Four surfactants were studied for their cytotoxic effect on human fibroblasts in culture. The surfactants were sodium dodecyl sulphate (SDS; anionic), cetyltrimethylammonium bromide (CTAB; cationic) and two nonionic compounds, octylphenoxy polyethoxyethanol (Triton X100) and polyoxyethylene (20) sorbitan monooleate (Tween 80). For each surfactant, LD(100)(More)
A range of surfactants, including the anionic sodium dodecyl sulfate, the cationic cetyltrimethylammonium bromide and the nonionics octylphenoxy polyethoxyethanol (Triton X100) and polyoxyethylene 20 sorbitan monoleate (Tween 80) was studied for effects on proliferation, contractibility and attachment of cultured human fibroblasts. Only ionic surfactants(More)