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The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
Blood vessel formation requires the integrated regulation of endothelial cell proliferation and branching morphogenesis, but how this coordinated regulation is achieved is not well understood. Flt-1Expand
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The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis.
Sprouting angiogenesis is critical to blood vessel formation, but the cellular and molecular controls of this process are poorly understood. We used time-lapse imaging of green fluorescent proteinExpand
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Gene expression profiling of the developing Drosophila CNS midline cells.
The Drosophila CNS midline cells constitute a specialized set of interneurons, motorneurons, and glia. The utility of the CNS midline cells as a neurogenomic system to study CNS development derivesExpand
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Single-cell mapping of neural and glial gene expression in the developing Drosophila CNS midline cells.
Understanding the generation of neuronal and glial diversity is one of the major goals of developmental neuroscience. The Drosophila CNS midline cells constitute a simple neurogenomic system to studyExpand
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Diagnostic implications of excessive homozygosity detected by SNP-based microarrays: consanguinity, uniparental disomy, and recessive single-gene mutations.
Single nucleotide polymorphism–based microarrays used in diagnostic laboratories for the detection of copy number alterations also provide data allowing for surveillance of the genome for regions ofExpand
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Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division.
Mice lacking the vascular endothelial growth factor (VEGF) receptor flt-1 die of vascular overgrowth, and we are interested in how flt-1 normally prevents this outcome. Our results support a modelExpand
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Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation.
New blood vessel formation requires the coordination of endothelial cell division and the morphogenetic movements of vessel expansion, but it is not known how this integration occurs. Here, we showExpand
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The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation.
Mice lacking the vascular endothelial growth factor (VEGF) receptor flt-1 (VEGFR-1) die from vascular overgrowth, caused primarily by aberrant endothelial cell division (Kearney JB, Ambler CA, MonacoExpand
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In vitro differentiation of mouse ES cells: hematopoietic and vascular development.
Publisher Summary Mouse ES cells have been differentiated in vitro since the mid-1980s, and vasculogenesis and hematopoiesis were among the earliest developmental processes studied using this model.Expand
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csf1 is required for early embryonic macrophage development: characterization of the csf1op/csf1op mutation in ES cell‐derived macrophages
Fedarko, N.S., Jain, A., Karadag, A., Van Eman, M.R. & Fisher, L.W. (2001) Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clinical Cancer Research, 7,Expand
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