Joseph Alexander

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BACKGROUND Statins, potent compounds that inhibit cholesterol synthesis in the liver have been reported to induce bone formation, both in tissue culture and in rats and mice. To re-examine potential anabolic effects of statins on bone formation, we compared the activity of simvastatin (SVS) to the known anabolic effects of PTH in an established model of(More)
It is well established that core binding factor Runx2/Cbfa1 is required for osteoblast recruitment and differentiation from mesenchymal stem cells. Transcriptional regulation of the Runx2/Cbfa1 gene by osteogenic factors such as bone morphogenetic proteins (BMPs) plays an important role in the stimulation of bone formation by these cytokines. BMP7 (also(More)
The comparative holding strength of cannulated screws (CS) versus solid core screws (SCS) has not been reported, although differences exist in the respective diameters of their outer thread and pilot drill holes. Our objectives were to characterize these differences and determine the holding power of CS compared with SCS in cortical and cancellous bone. The(More)
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