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  • Denis Riendeau, Michael David Percival, +22 authors Chi Chung Chan
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2001 (First Publication: 1 February 2001)
  • We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) pyridine], a novel orally active agent that selectively inhibitsExpand
  • Denis Riendeau, Michael David Percival, +22 authors Chi Chung Chan
  • Medicine, Chemistry
  • British journal of pharmacology
  • 1997 (First Publication: 1 May 1997)
  • 1. DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furan one) was identified as a novel orally active and highly selective cyclo-oxygenase-2 (COX-2) inhibitor. 2. In CHO cellsExpand
  • Joseph A. Mancini, Katherine Blood, +4 authors Denis Riendeau
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2001 (First Publication: 9 February 2001)
  • We have cloned and expressed the inducible form of prostaglandin (PG) E synthase from rat and characterized its regulation of expression in several tissues after in vivolipopoylsaccharide (LPS)Expand
  • C. C. Chan, Susan Boyce, +22 authors Ian W. Rodger
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1999
  • The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (PGs) in theExpand
  • Denis Riendeau, Stella Charleson, Wanda Cromlish, Joseph A. Mancini, Elizabeth Wong, J A Guay
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1997 (First Publication: 1 September 1997)
  • Two forms of cyclooxygenase (COX) activity are involved in the synthesis of prostaglandins, prostacyclins, and thromboxanes in mammalian cells. There is now convincing evidence, obtained with aExpand
  • Louise Boulet, Marc Ouellet, +5 authors Nathalie Méthot
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2004 (First Publication: 28 May 2004)
  • Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible protein recently shown to be an important source of inflammatory PGE2. Here we have used mPGES-1 wild type, heterozygote, and null miceExpand
  • P J Jakobsson, Ralf Morgenstern, Joseph A. Mancini, Anthony W. Ford-Hutchinson, Bengt Persson
  • Medicine, Biology
  • Protein science : a publication of the Protein…
  • 1999 (First Publication: 31 December 2008)
  • A novel superfamily designated MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism), including members of widespread origin with diversified biological functions is definedExpand
  • Daigen Xu, Steven E. Rowland, +10 authors Denis Riendeau
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2008 (First Publication: 1 September 2008)
  • Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E2 (PGE2) synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE2 production and relieve inflammatoryExpand